Barbituric acid on a watchglass
| IUPAC name
| Other names
1,3-Diazinane-2,4,6-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Trioxohexahydropyrimidine; 2,4,6-Trihydroxypyrimidine; 2,4,6-Trioxypyrimidine; 2,4,6-Pyrimidinetriol; 2,4,6-Pyrimidinetrione; 2,4,6-Trihydroxy-1,3-diazine; 6-Hydroxy-hydrouracil; 6-Hydroxyuracil; Malonylurea; Pyrimidinetriol; N,N-(1,3-dioxo-1,3-propanediyl)urea; N,N-Malonylurea
|Molar mass||128.09 g/mol|
|Melting point||245 °C (473 °F; 518 K)|
|Boiling point||260 °C (500 °F; 533 K) (decomposes)|
|14.2 g/100 ml (20 °C)|
|Solubility|| Soluble in formaldehyde 37%, conc. formic acid|
Slightly soluble in pyridine
Almost insoluble in HCl 37%
Insoluble in glacial acetic acid, acetone, acetonitrile, alcohols, ammonia 25%, chloroform, dichloromethane, ethyl acetate, heptane, hexane, methyl acetate, toluene, xylene
|Safety data sheet||Sigma-Aldrich|
|Lethal dose or concentration (LD, LC):|
LD50 (Median dose)
|5,000 mg/kg (rat, oral)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Barbituric acid or malonylurea is an organic compound based on a pyrimidine heterocyclic skeleton. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active.
Barbituric acid will form a colored complex with pyridine and cyanide.
Barbituric acid is a white solid, moderate soluble in water and insoluble in most organic solvents, but shows good solubility in aq. formaldehyde and conc. formic acid. Solutions of barbituric acid will oxidize in air, turning yellow then brownish after several hours and days. It has a weak odor.
Barbituric acid is sold by chemical suppliers, however it is classified as controlled substance in most countries, making it near impossible for the amateur chemist to acquire it freely.
- Make vitamin B2 (riboflavin)
- Make pyridine/barbituric acid reagent (cyanide detection)
Barbituric acid should be handled with care and proper protection.
Overdose of barbituric acid can cause respiratory problems and death. Barbituric acid derivatives are considered DEA Schedule III controlled substances.
In closed bottles.
Can be poured down the drain.