Quinine

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Not to be confused with quinone.
Quinine
Names
IUPAC name
(R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol
Other names
Chinine
Qualaquin
Quinate
Quinbisul
Properties
C20H24N2O2
Molar mass 324.42 g/mol
Appearance White solid
Odor Odorless
Melting point 177 °C (351 °F; 450 K)
Boiling point Decomposes
0.05 g/100 ml (15 °C)
Solubility Soluble in carbon disulfide, chloroform, ethanol
Slightly soluble in glycerol
Insoluble in ammonia, petroleum ether
Solubility in benzene 1.25 g/100 ml
Solubility in chloroform 83.3 g/100 ml
Solubility in diethyl ether 0.4 g/100 ml
Solubility in ethanol 125 g/100 ml
Solubility in glycerol 5 g/100 ml
Vapor pressure 1.54·10-10 mmHg at 25 °C
Hazards
Safety data sheet Sigma-Aldrich
Lethal dose or concentration (LD, LC):
1,800 mg/kg (guinea pig, oral)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Quinine is an alkaloid isolated from Cinchona bark, used as medication to treat malaria and babesiosis.

Properties

Chemical

Quinine reacts with acids forming water soluble salts.

Quinine will slowly oxidize upon exposure to air over long periods of time, in both free and salt form, turning dark.

Physical

Quinine is a colorless or white solid, with a potent bitter taste.

Availability

Quinine is sold online. Often, it is sold in salt form, as sulfate.[1]

Tonic water has small amounts of quinine, though not enough for it to be an economical source.

Preparation

Quinine is best extracted from Cinchona tree bark than synthesized from precursors.

Projects

  • Compound collecting
  • Bitter taste mixtures
  • Tonic water
  • Make fluorescent drinks
  • Anti-malaria drug
  • Demonstration of triboluminescence

Handling

Safety

Exposure to quinine is known to cause abnormal heart rhythms.

Storage

Quinine should be kept in plastic or glass bottles, in dark places.

Disposal

Can be safely poured down the drain or in trash.

References

  1. https://www.ebay.com/p/Quinine-Sulfate-Dihydrate-99-titration-Powder-50g/1648490218

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