Difference between revisions of "Nicotinamide"
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Latest revision as of 18:41, 11 January 2020
| IUPAC name
| Other names
Nicotinic acid amide
|Molar mass||122.127 g/mol|
|Density||1.40 g/cm3 (25 °C)|
|Melting point||129.5 °C (265.1 °F; 402.6 K)|
|Boiling point||334 °C (633 °F; 607 K) (decomposes)|
|50 g/100 ml (25 °C)|
|Solubility|| Soluble in acetone, butanol, chloroform, ethanol, ethylene glycol, pentanol|
Slightly soluble in benzene
|Vapor pressure||4.2·10-4 mmHg at 25 °C|
|Safety data sheet||Sigma-Aldrich|
|Flash point||182 °C (360 °F; 455 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (Median dose)
| 3,530 mg/kg (rat, oral)|
2,000 mg/kg (rabbit, dermal)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Nicotinamide (NAM), also known as niacinamide, is a form of vitamin B3 found in food and used as a dietary supplement and medication. It is an amide of nicotinic acid.
Niacinamide readily hydrolyzes to free acid by heating it in acid or alkaline solution.
Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP).
Niacinamide is a white solid, odorless, with a bitter taste.
Niacinamide is sold by food stores and pharmacies, in pure form or as tablets.
Can also be bought online.
The hydrolysis of nicotinonitrile yields niacinamide.
However, it's much cheaper to just buy the substance from sellers.
- Make 3-aminopyridine
- Make 2-chloronicotinonitril
- Food supplement
- Stabilizer for acetaldehyde
Niacinamide has low toxicity and is not irritant. Consumption of pure nicotinamide has minimal side effects. At high doses however, liver problems may occur. Normal doses are safe during pregnancy.
In closed bottles or bags.
No special disposal is required. Discard it as you wish.