https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&feed=atom&action=history
Warfarin - Revision history
2024-03-28T12:03:03Z
Revision history for this page on the wiki
MediaWiki 1.25.1
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=14984&oldid=prev
Mabus: /* Relevant Sciencemadness threads */
2023-05-27T15:13:31Z
<p><span dir="auto"><span class="autocomment">Relevant Sciencemadness threads</span></span></p>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 15:13, 27 May 2023</td>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://www.sciencemadness.org/talk/viewthread.php?tid=159453 Warfarin syntheses]</ins></div></td></tr>
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Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=13780&oldid=prev
Mabus at 23:08, 3 January 2021
2021-01-03T23:08:44Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 23:08, 3 January 2021</td>
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<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Warfarin should kept in sealed vials, with a proper hazardous chemical label.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Warfarin should kept in sealed vials, with a proper hazardous chemical label<ins class="diffchange diffchange-inline">, in a locked cabinet</ins>.</div></td></tr>
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Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=13031&oldid=prev
Mabus at 17:17, 1 June 2020
2020-06-01T17:17:08Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 17:17, 1 June 2020</td>
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Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=12638&oldid=prev
Mabus at 18:28, 16 February 2020
2020-02-16T18:28:05Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 18:28, 16 February 2020</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Physical===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Physical===</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Warfarin is a colorless solid, odorless and tasteless. It is almost insoluble in water, but more soluble in some organic solvents, like [[acetone]], halogenated solvents ([[chloroform]]), [[dioxane]].</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Warfarin is a colorless solid, odorless and tasteless. It is almost insoluble in water, but more soluble in some organic solvents, like [[acetone]], halogenated solvents ([[chloroform]] <ins class="diffchange diffchange-inline">e.g.</ins>), [[dioxane]] <ins class="diffchange diffchange-inline">and somewhat soluble in alcohols</ins>.</div></td></tr>
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Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=12012&oldid=prev
Mabus at 18:27, 1 October 2019
2019-10-01T18:27:49Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 18:27, 1 October 2019</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Warfarin''', sold under the brand name '''Coumadin''' among others, is an organic chemical compound, used and sold as anticoagulant (blood thinner) in medicine.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Warfarin''', sold under the brand name '''Coumadin''' among others, is an organic chemical compound, used and sold as anticoagulant (blood thinner) in medicine <ins class="diffchange diffchange-inline">and as rat poison</ins>.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
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Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=11814&oldid=prev
Mabus at 05:02, 27 July 2019
2019-07-27T05:02:52Z
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</tr><tr><td colspan="2" class="diff-lineno" id="L141" >Line 141:</td>
<td colspan="2" class="diff-lineno">Line 141:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Storage===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Storage===</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">In </del>sealed vials, with a proper hazardous chemical label.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Warfarin should kept in </ins>sealed vials, with a proper hazardous chemical label.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Disposal===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Disposal===</div></td></tr>
</table>
Mabus
https://www.sciencemadness.org/smwiki/index.php?title=Warfarin&diff=11577&oldid=prev
Mabus: Created page with "{{Chembox | Name = Warfarin | Reference = | IUPACName = (RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one | PIN = | SystematicName = | OtherNames = 4-hydroxy-2-oxo-3-(3..."
2019-06-23T12:45:57Z
<p>Created page with "{{Chembox | Name = Warfarin | Reference = | IUPACName = (RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one | PIN = | SystematicName = | OtherNames = 4-hydroxy-2-oxo-3-(3..."</p>
<p><b>New page</b></p><div>{{Chembox<br />
| Name = Warfarin<br />
| Reference =<br />
| IUPACName = (RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one<br />
| PIN =<br />
| SystematicName =<br />
| OtherNames = 4-hydroxy-2-oxo-3-(3-oxo-1-phenyl-butyl)-2H-chromene<br>4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one<br>Coumadin<br>Coumafene<br>Prothromadin<br />
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<!-- Sections --><br />
| Section1 = {{Chembox Identifiers<br />
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| Section2 = {{Chembox Properties<br />
| AtmosphericOHRateConstant = <br />
| Appearance = White solid<br />
| BoilingPt = <br />
| BoilingPtC = <br />
| BoilingPt_ref = <br />
| BoilingPt_notes = Decomposes<br />
| Density = 1.4 g/cm<sup>3</sup><br />
| Formula = C<sub>19</sub>H<sub>16</sub>O<sub>4</sub><br />
| HenryConstant = <br />
| LogP = 2.70<br />
| MolarMass = 308.333 g/mol<br />
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| Odor = Odorless<br />
| pKa = 5.87<br />
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| Solubility = 0.17 g/100 ml (20 °C)<br />
| SolubleOther = Soluble in [[acetone]], [[chloroform]], [[dichloromethane|DCM]], [[dioxane]]<br>Moderately soluble in [[ethanol]], [[isopropanol]], [[methanol]], some oils<br>Freely soluble in alkaline aqueous solution (forms a water-sol sodium salt)<br>Practically insoluble in [[benzene]], [[cyclohexane]], [[hexane]], [[pentane]]<br />
| Solubility1 = 6.5 g/100 ml (20 °C)<br />
| Solvent1 = acetone<br />
| Solubility2 = 5 g/100 ml (20 °C)<br />
| Solvent2 = chloroform<br />
| Solubility3 = 10 g/100 ml (20 °C)<br />
| Solvent3 = dioxane<br />
| VaporPressure = 0.09 mmHg at 20 °C<br />
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| ExternalMSDS = [http://www.hmdb.ca/system/metabolites/msds/000/001/525/original/Warfarin_MSDS.pdf?1368653709 DuPont]<br />
| FlashPt = <br />
| LD50 = 1.6 mg/kg (rat, oral)<br />
| LC50 = <br />
| MainHazards = Toxic<br />
| NFPA-F = <br />
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'''Warfarin''', sold under the brand name '''Coumadin''' among others, is an organic chemical compound, used and sold as anticoagulant (blood thinner) in medicine.<br />
<br />
==Properties==<br />
===Chemical===<br />
Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.<br />
<br />
===Physical===<br />
Warfarin is a colorless solid, odorless and tasteless. It is almost insoluble in water, but more soluble in some organic solvents, like [[acetone]], halogenated solvents ([[chloroform]]), [[dioxane]].<br />
<br />
==Availability==<br />
Warfarin is sold in pharmacies, though it can only be acquired via prescription.<br />
<br />
It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.<br />
<br />
==Preparation==<br />
Warfarin can be prepared from coumarin, which itself can be obtained from the fermentation of sweet clover, though the amount obtained from this route is very small to be practical. It's better to use synthetic coumarin as precursor.<br />
<br />
A much quicker route involves 4-hydroxycoumarin and benzalacetone. The reaction produces racemic warfarin.<br />
<br />
==Projects==<br />
*Pesticide<br />
*Compound collecting<br />
<br />
==Handling==<br />
===Safety===<br />
Warfarin is toxic if ingested and large amounts may lead to death. Vitamin K is used as antidote.<br />
<br />
===Storage===<br />
In sealed vials, with a proper hazardous chemical label.<br />
<br />
===Disposal===<br />
Should be destroyed with an oxidizing mixture, like [[chromic acid]], [[Fenton's reagent]] or [[piranha solution]].<br />
<br />
==References==<br />
<references/><br />
===Relevant Sciencemadness threads===<br />
<br />
[[Category:Chemical compounds]]<br />
[[Category:Organic compounds]]<br />
[[Category:Lactones]]<br />
[[Category:Blood agents]]<br />
[[Category:Things that can kill you very quickly]]<br />
[[Category:Things that should NOT be messed with except by professionals]]<br />
[[Category:Solids]]</div>
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