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The Pfitzinger Reaction
Pfitzinger reaction of isatin used to prepare:
1. Quinacainol
2. Pavinetant
3. Oxycinchophen
4. ...
7-1-2025 at 00:31
by: Illegal Parkinson
Ethyl Phenylcyanoacetate Synthesis troubles
Frederick Dr Leonard, CH369764 (163 to Geigy).

Methyl 3-amino-2-phenylpropanoate
[99092-02-1]
...
7-11-2024 at 00:31
by: Illegal Parkinson
Drug Database Link
[rquote=672107&tid=158363&author=veryoldbutstilluninjured]this resource may also be of inter ...
6-11-2024 at 03:10
by: Illegal Parkinson
Drug Database Link
Okay here is the new version: https://www.mediafire.com/file/p63erdgbyg4z0bu/Drug_Database.zip/file
...
6-11-2024 at 03:09
by: Illegal Parkinson
Drug Database Link
It's been about 2.5 years since I gave you that collection of files.

Let me know if anyone is int ...
3-8-2024 at 06:16
by: Illegal Parkinson
Epinicline
yes it's the same compound.

I changed the name to Epinicline because I could not decide iwhether ...
29-7-2024 at 23:43
by: Illegal Parkinson
Epinicline
This name is a cross between epibatidine and tebanicline.

I found a related structure on pubchem ...
28-7-2024 at 09:02
by: Illegal Parkinson
2-chloroacridin-9(10H)-one synthesis
I wondered if this reaction could work in acid.

2-Amino-5-chlorobenzophenone
[719-59-5]

2-chl ...
16-7-2024 at 00:53
by: Illegal Parkinson
Drug Database Link
This is my own personal collection of homebrew efforts i have made into drug discovery since graduat ...
13-2-2022 at 03:35
by: Illegal Parkinson
Drug Database Link
This is a big database. Considering I obtained my masters in 2004, that's 18 years of post graduate ...
12-2-2022 at 01:17
by: Illegal Parkinson
Drug Database Link
Here is an alternate place to store it:

https://www.mediafire.com/file/dgc2uy3jlfyj5er/Drug+Datab ...
11-2-2022 at 01:40
by: Illegal Parkinson
Drug Database Link
Are you able to access it?

The file search does not seem to work as well as on onecloud.

Mega ...
9-2-2022 at 23:49
by: Illegal Parkinson
Drug Database Link
I made a drug database available to view.

https://aspera.pub/Wxi-c-U

This is the Feb 2022 edit ...
9-2-2022 at 12:55
by: Illegal Parkinson
Dibenzo[b,f]oxepin-10(11H)-one [5024-70-4]
I got a whole army of RMI # codenumbers from pubchem if someone can help me.

Potentially, Thiosal ...
9-2-2022 at 07:19
by: Illegal Parkinson
Dibenzo[b,f]oxepin-10(11H)-one [5024-70-4]
Here is the reaction i am interested in:
8-2-2022 at 06:43
by: Illegal Parkinson
Dibenzo[b,f]oxepin-10(11H)-one [5024-70-4]
If see Xanthone page on wiki, it says it was made from phenyl salicylate.

By a straight analog th ...
27-1-2022 at 03:05
by: Illegal Parkinson
Ketalization of Phenol
I found this also, if anybody interested:

https://de.wikipedia.org/wiki/Cyclohexadienone

http ...
6-5-2021 at 11:05
by: Illegal Parkinson
Ketalization of Phenol
I found online evidence that salicylic acid can be made to exist in the tautomeric keto form under c ...
5-5-2021 at 09:27
by: Illegal Parkinson
Ketalization of Phenol
Even supposing the whole thing is bogus, one last attempt is 1,3-Cyclohexadiene [4 + 1] Nitrene cycl ...
4-5-2021 at 10:22
by: Illegal Parkinson
Ketalization of Phenol
The benzoquinone is another interesting method.

If you form a thioketal, if the olefin tautomeriz ...
4-5-2021 at 09:32
by: Illegal Parkinson
Ketalization of Phenol

Yeah but you have 2 strong electron withdrawing groups which would disrupt the aromaticity. Come t ...
4-5-2021 at 09:09
by: Illegal Parkinson
Ketalization of Phenol
Anyway, I got to the bottom of it now anyway.

After reading Zhang & Trudell's article again: ...
4-5-2021 at 00:36
by: Illegal Parkinson
Ketalization of Phenol
E.g. Wu, Q., Hu, J., Ren, X., & Zhou, J. S. (2011). An Efficient, Overall [4+1] Cycloadditon of ...
1-5-2021 at 03:36
by: Illegal Parkinson
Ketalization of Phenol
The only problem with using Phloroglucinol as the starting material is that it is made from trinitro ...
1-5-2021 at 03:16
by: Illegal Parkinson
Preparation of Benzyl Chloride
Where do you aspire that you are going with this synthesis?

The reaction of 2 equivalents with 1 ...
28-4-2021 at 07:42
by: Illegal Parkinson
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