Method (f).
Potassium hydroxide (0.56 g) was added to a solution of 1.40 g of 3-methyl-4-piperidone hydrochloride
[9, 10] in 12 ml of water, and then with ice cooling,0.20 g of NaBH 4 in 5 ml of water was added. The
mixture was left at 20 ~ for two hours, acidified with 1.7 ml of concentrated hydrochloric acid, and evaporated
down to about 2 ml; the base was liberated by the action of K2CO a and extracted with chloroform. [Followed by the description of the methylation of
the amine with paarformaldehdye/hydrogenation] |