Jackson - 23-4-2019 at 08:23
Could a reduction of p-aminophenol to aniline through the use of zinc dust work? I am looking to synthesize aniline without going through nitrobenzene
or benzene, but also with relatively OTC compounds (p-aminophenol could be obtained from acetaminophen). Would a Hoffman rearrangement of benzamide
obtained from Benzoic acid be better?
draculic acid69 - 25-4-2019 at 04:44
I wonder if para amino benzoic acid can be reacted like sodium benzoate and NaOH to yeilds aniline?going through benzene and nitrobenzene and a
reduction seems tedious.paracetamol has a hydroxy that would be hard to get rid of.but it is super cheap and easy.
Chemi Pharma - 10-5-2019 at 23:37
You can convert phenols to anilines via Smiles rearrangement using Chloroacetamide, KI, K2CO3 and DMF, like said in the paper I attached. So, a better
route to your target, since you don't want to use benzene or nitrobenzene, is starting from phenol and convert it into aniline this way. If you start
from p-aminophenol you will get p-Phenylenediamine.
You can start from Chlorobenzene, amonea and cooper oxide under heat and pressure to obtain aniline either.
Attachment: phenols to anilines with chloroacetamide, K2CO3, KI and DMF.PDF (1.9MB)
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