Quote: Originally posted by smuv | First of all, where are you getting info for DMSO being used for bromohydrin formation? If you saw it used for an aromatic bromination with NBS,
don't think for a second that it would be a good idea for this reaction. |
Water/DMSO is fairly standard for bromohydrin formation with NBS, as far as I am aware. So much so, that it was one of the examples in my undergrad
organic chem class when teaching about halohydrin synthesis.
I don't have access, but this is referenced in several places and the abstract is fairly telling:
DOI: 10.1039/J29710000085 |