vibbzlab - 6-11-2019 at 22:24
Do anyone have a procedure for synthesis of sulfosalicylic acid?
I was planning of protein analysis and I need that reagent. I already have the salicylic acid. I was wondering if adding concentrated Sulfuric acid
would help me make it or is there a procedure ? If someone knows please do comment
VSEPR_VOID - 7-11-2019 at 12:52
http://www.sciencemadness.org/talk/viewthread.php?tid=24147
Here
vibbzlab - 7-11-2019 at 16:03
I am unable to open any pdf in that link. I tried downloading but it says I can't open file
VSEPR_VOID - 8-11-2019 at 14:15
Attachment: sulfosalicylic acid.pdf (317kB)
This file has been downloaded 320 times
vibbzlab - 8-11-2019 at 22:50
Thanks. I am currently doing the procedure for synthesis of sulfosalicylic acid
vibbzlab - 13-11-2019 at 06:39
I heated the salicylic acid with Sulfuric acid and everything dissolved but after I kept it in boiling water bath for about 30min it became black. Is
it normal or did it get charred?
Ubya - 13-11-2019 at 08:37
surely some tar has formed, how much tar you'll see when you calculate the yield
vibbzlab - 13-11-2019 at 10:01
I could not get crystals even by cooling it
Tsjerk - 13-11-2019 at 11:06
Did you try to crystallize from cold saturated brine as Hexavalent did in 2013?
I do wonder how he got to his yield... I think he expected it to be the dihydrate (probably right) but turned around the 7 and the 8 in his yield.
vibbzlab - 13-11-2019 at 16:11
Yes I tried it in saturated brine
vibbzlab - 24-11-2019 at 03:48
Man I tried my best but I am getting unsuccessful in that last step of sulfonation. On adding Sulfuric acid and heating the whole thing gets charred
Pumukli - 24-11-2019 at 04:57
Which recipe are you following?
Sulfonating aspirin or sulfonating salycilic acid is not the same! In the later case the phenol is not protected so it is much more sensitive to
oxidation and the ring is more susceptible to sulfonation so concentrated sulfuric acid is probably way too much!
Try to find a proper recipe that matches your starting materials!
Boffis - 24-11-2019 at 05:57
@vibbzlab; Some time ago I posted links to the 4 volumes of Welcher "Organic analytical reagent". In volume 2 it describes the preparation of this
reagent. If you get a black charr you have simply overheated it.
vibbzlab - 24-11-2019 at 07:28
Can I have that link.where to get it
Boffis - 24-11-2019 at 08:51
Hi vibbzlab here it is:
https://archive.org/search.php?query=organic%20analytical%20...
Cut and paste this link into your browser if it is not dynamic