I want to reduce some nitrovanillin to the amine. Ive heard of zinc and iron dissolved in HCl being used, but I can’t find any procedures on it.
Does anyone know at least a basic outline of one of these aromatic nitro group reductions?
Thanks.ArbuzToWoda - 13-11-2020 at 08:46
These reductions can sometimes get a tiny bit messy. I recommend the use of sodium dithionite or thiourea dioxide instead. You should be able to find
many situations of the Fe/HCl reduction too though, where did you search? This looks interesting for example: https://www.researchgate.net/publication/274084261_Chemosele...monolithic - 13-11-2020 at 09:23
If you insist on using a dissolving metal reduction then that's ok, but I second thiourea dioxide. Very straightforward to use and cheap.Chem Science - 13-11-2020 at 11:45
Thanks guys. ill probably update later to tell you how it went. I’m gonna try the Trimethoxynitrostyrene Method that was mentioned. I expect higher
than 20% yield because zinc/HCl reductions are known to give crap yeilds on non-aromatic nitro groups.
