Sciencemadness Discussion Board

Alternative solvent for the delepine reaction.

Triflic Acid - 26-12-2020 at 20:47

I am trying to make an amine, starting from a bromide. I am trying to find a better solvent than chloroform, preferably one that is environmentally better than CHCl3. I heard that ethanol can be used in another and that it gives better yields. I was wondering if there was any other solvent that could be used, because I might have time to test a bunch of solvents for a process that I am trying to optimize.

Antigua - 27-12-2020 at 03:57

https://scihub.wikicn.top/https://pubs.acs.org/doi/abs/10.10...

RustyShackleford - 27-12-2020 at 04:28

I have tried ethanol and acetic acid, ethanol was better. Substrate was benzyl chloride.

Triflic Acid - 27-12-2020 at 21:24

@Antigua thanks for that paper.