I think it might be interesting to sell things which are more stable, higher priced replacements for cheap, hazardous reagents. In principle, you
could buy the cheap reagent and upgrade it yourself in a step or two, then get a significant profit margin.
E.g. 1,1'-oxalyldiimidazole, the rxn product of oxalyl chloride and imidazole. Very effective carboxylic acid activation reagent with none of the
volatility of oxalyl chloride.
Another possibility is Ms2O, which activates alcohols with no volatile hydrolysis byproduct (contrast TsCl or PBr3). MsOH is dehydrated by P2O5 or
even, IIRC, Ac2O (by Le Chatelier removing AcOH).
TsNHNH2, KOtBu, Bu4NBr (not really a replacement), probably some others I'm not thinking of. |