Sciencemadness Discussion Board

Free Offline Databases for Chemists: Organic Synthesis

NinjaChemist - 8-2-2026 at 03:53

Hi everyone, NinjaChemist is here

If you’ve ever tried hunting down a specific synthesis via Google, you know how frustrating and hit-or-miss it can be. To make life easier, I’m sharing two databases I’ve put together for searching synthetic methodologies.

Both databases run on DataWarrior (a free, open-source chemoinformatics tool). I’ve included the software(official build) in the archive just in case you don't have it installed.

1. The Reference & Handbook Database
Content: 50,000 procedures sourced from classic textbooks and laboratory manuals.

Search: Supports structure and substructure searching.

Scope: Includes organic and some inorganic substances.

Note on Language: This was originally developed for a Russian-speaking audience, so about 2/3 of the procedures are in Russian. However, it is still very usable for English speakers: 1/3 is already in English, and for the rest, you can simply feed the text/files into Gemini or ChatGPT for instant digitizing and translation.

Integration: The source books are included in the archive and can be opened directly via links in the database. Please read the "readme" file to set up the file paths so the links work correctly.

Best for: Standard procedures and relatively straightforward compounds. This is my go-to for daily lab work.

2. The Reaction Database (Spresi + Supplemental)
Spresi: ~2.5 million reactions.

Unknown Database(possibly early Beilstein dump): ~250,000 reactions.

Search: Full reaction search (structure/substructure, product, and/or reagent).

Best for: Complex molecules, rare syntheses, and deeper literature reviews.

Links & Media
Video Presentation, reccomended for watch for additional tips and tricks:

https://youtu.be/lCJEr5bnjUU

https://youtu.be/w54fxFIO_Xc

Download from telegram(archive + torrent files):
https://t.me/ninja_chemist/23
https://t.me/ninja_chemist/25

Magnet Links (Torrent):
Code:
magnet:?xt=urn:btih:3901b7ed8ce3d686de98552537fde6a5b4d9871b&dn=spresi_data_base.7z&xl=480337379&tr=udp%3A%2F%2Ftracker.opentrackr.org%3A1337%2Fannounce&tr=udp%3A%2F%2Fopen.stealth.si%3A80%2Fannounce&tr=udp%3A%2F%2Ftracker.torrent.eu.org%3A451%2Fannounce&tr=udp%3A%2F%2Fexodus.desync.com%3A6969%2Fannounce&tr=udp%3A%2F%2Ftracker.moeking.me%3A6969%2Fannounce&tr=udp%3A%2F%2Ftracker.openbittorrent.com%3A6969%2Fannounce&tr=udp%3A%2F%2F9.rarbg.com%3A2810%2Fannounce
Code:
magnet:?xt=urn:btih:13717dd92ca136275a502c1e1633081905cccd7e&dn=synthesis_data_base&xl=6595232261&tr=udp%3A%2F%2Fopen.stealth.si%3A80%2Fannounce&tr=udp%3A%2F%2Ftracker.torrent.eu.org%3A451%2Fannounce&tr=udp%3A%2F%2Fexodus.desync.com%3A6969%2Fannounce&tr=udp%3A%2F%2Ftracker.moeking.me%3A6969%2Fannounce&tr=udp%3A%2F%2Ftracker.openbittorrent.com%3A6969%2Fannounce&tr=udp%3A%2F%2F9.rarbg.com%3A2810%2Fannounce&tr=udp%3A%2F%2Ftracker.opentrackr.org%3A1337%2Fannounce


A quick note: I tried uploading these to the Internet Archive, but the upload kept failing. If anyone manages to mirror these to the Web Archive, please post the link in this thread!

teodor - 10-2-2026 at 15:00

Interesting. Did you include ChemInform abstracts also? I think this is one of most comprehensive source of such type of information.
Also Houben - Weyl is another excelent source.

But surely I will check your DB to compare. And I am fluent in Russian :)

NeonCortex - 19-2-2026 at 16:01

U DA MAN! Will check it out. Thanks!