synthetic.madness - 16-11-2012 at 08:23
Is reflux under alkaline conditions (3M NaOH (aq.)) sufficient to hydrolyze most sulfanamides? I was thinking of the hydrolysis of sodium cyclamate in
particular, which would make for an OTC route to cyclohexylamine, however, all the references I can find refer to fairly extreme acidic conditions...
(i.e. http://pubs.acs.org/doi/abs/10.1021/ac60258a033 which calls for heating sodium cyclamate with conc. HCl under pressure)
Structure of sodium cyclamate: http://upload.wikimedia.org/wikipedia/commons/6/65/Cyclamate...