morganism - 13-2-2013 at 15:18
Using bio catalysts to make handed isomers with amino acids, alcohols and amines. Low temp too...
http://www.sciencedaily.com/releases/2013/02/130213132317.ht...
kavu - 13-2-2013 at 15:31
It's a neat workaround, but it's not anything substantially novel. Organocatalysis is nowadays a vibrant field and much research is going on in many
universities.
[Edited on 13-2-2013 by kavu]
zed - 15-2-2013 at 16:53
Worst writing ever. The article endeavors to relay some information....apparently.
smaerd - 16-2-2013 at 12:23
Tried finding an article because yea that article was completely unintelligable...People have long used enantiomers of amino acids for chiral
resolutions and enantioselective reactions in one way or another. They really should have just posted the abstract of the article and a citation
hahaha.
http://www.nature.com/nature/journal/v494/n7436/full/nature1...
Dr.Bob - 17-2-2013 at 20:09
It is a nice paper, but limited to mostly allyl boron additions, and some related compounds. While the chemistry is very useful for those, that is a
fairly limited reagent, being added to a glycine phophoryl-imine, which is not a very common starting material either. But I am sure that Aldrich or
someone will start selling it soon. It would be nice to see a more general chiral catalytic addition reaction, but most catalyst are pretty
specific, and only a few chiral catalysts are useful for many substrates. This chemistry is complementary to the most common way to make chiral
amino acids by cat. hydrogenation, which is used to make phenylglycine and related AAs in ton amounts. But it would not work well for allyl
compounds, as they would likely be reduced as well.