chemisch - 5-3-2013 at 21:25
figured cleaving the hydroxide would be easy. I realize this is a very simply reaction as its done metabolically but any suggestions?
[Edited on 6-3-2013 by chemisch]
solo - 6-3-2013 at 09:17
Reference Information
LC-MS of novel narcoepileptics and related substances
Ramisetti Nageswara Rao, Dhananjay D. Shinde
J. Sep. Sci.
2009, 32, 1312 – 1322
Abstract
Modafinil, adrafinil and their related substances were synthesized and analyzed by RP-LC with ESI-MS/MS. The ionization mode, polarity, cone voltage,
and chromatographicconditions were evaluated. The optimum LC-MS conditions to obtain fragment
ions indispensable for identification of the structures were described. The bulk drugs purity of modafinil and adrafinil was evaluated on Kromasil C18
column with ACN/0.02 M ammonium acetate as mobile phase in gradient elution mode at 308C. The method was found to be suitable not only for monitoring
the reactions during the process development but also for quality assurance of modafinil and adrafinil.
Attachment: LC-MS of novel narcoepileptics and related substances.pdf (1.2MB)
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chemisch - 8-3-2013 at 09:52
Interesting but I don't plan a complete synthesis. And those reagents don't exactly scream garage chemist. Maybe a nh3 or nh4 would work?