Could one perform an akabori on piperonal to yield MD-PPA then further take this to an MD-4MAR equiv. with sodium cyanate?
With the extended activity of 4MAR, this seems like it could be one interesting phenethylamine...joe_aldehyde - 13-9-2005 at 05:41
haha...UTFSE i asked that a while ago. sandmeyer said that methoxy-substituted
phenyloxazolines have decreased activity compared to the unsubstituted one.
but what about p-fluorophenyl-oxazoline...
ah and forget about akabori, it seems like no one that attempted it ever got something useful out of it, strange enough. condense the aldehyde with
nitroethane in presence of a tertiary (alkanol)amine.
[Edited on 13-9-2005 by joe_aldehyde]
Europhoric analogues
Kinetic - 13-9-2005 at 06:09
Quote:
sandmeyer said that methoxy-substituted phenyloxazolines have decreased activity compared to the unsubstituted one.
Para-fluoro-4-methylaminorex is not really worth making either. I made it a couple of years ago from 4-fluoropropiophenone. Bandil posted a bioassay
of his 4-fluoro-4-MAR at the Hive a couple of years ago too. His synthesis can be found here: http://www.erowid.org/archive/rhodium/chemistry/para-fluoro-...
My experience was a little better than his, but it was not interesting enough to warrant making it again. There are certainly more interesting things
to focus on. I still wonder what 4-ethylaminorex will be like.joe_aldehyde - 14-9-2005 at 00:24
i asked that a while ago. sandmeyer said that methoxy-substituted
phenyloxazolines have decreased activity compared to the unsubstituted one.