Sciencemadness Discussion Board

Friedel-Crafts Acylation Of Bromobenzene

Colli - 9-4-2006 at 14:38

Please help...?

I'm doing the mechanism of reaction for the friedel-crafts acylation of bromobenzene, using acetic anhydride, aluminium chloirde and dichloromethane... I've washed the organic product with dichloromethane, water, 2m naoh, and half saturated solution of nacl.

I just can't figure out what other products can be formed from this reaction other than 4-bromoacetophenone...? Bromine is ortho, para directing and the acetyl group is meta directing and strongly deactivating, right? So, how could any other product be favoured?

:o:(

[Edited on 9-4-2006 by Colli]

praseodym - 9-4-2006 at 21:10

I think this may be able to help you: