shrent - 11-5-2006 at 08:51
Hi Dears !
I made a Cycloaliphatic Amine by reduction of its oxime. Amine received as mixture of CIS & TRANS isomers & it has been quite tedious to
remove the cis isomer completely as I want only the trans amine.
Can I know about any reagents/procedure thro' which this cis amine can be converted to the trans isomer ?
Somewhere I read that some lewis acids could be used for this transformation.......but not sure.......
Pls comment......
shrent
chemoleo - 11-5-2006 at 09:54
You'll have to convert your 50% cis amine to the imine (R2C=NH), and reduce this to get the racemic mix. From this you can isolate the trans variety.
So your total yields will go up incrementally... 50%, 75%, 87.5 etc etc
shrent - 11-5-2006 at 21:03
Thanks a lot for the suggetion, dear !
But can you please explain this experimentally in detail ? Otherwise any exp. reference for this ?