enkay - 7-6-2006 at 05:33
Hi !
I'm trying Bromination of 4-Phenyl Butyric acid to get 2(alpha)-Bromo-4-Phenylbutyric acid.
Is this synthesis possible using Bromine liq. & 4-Phenylbutyric acid with any procedure ?
Awaiting your replies !
Thanks in advance,
Enkay
enkay - 9-6-2006 at 09:07
Again, one more question to my above posting......
Is this bromination possible using any bromine containing reagents instead of hazardous bromine liq. ? 
=SkyNET= - 9-6-2006 at 09:47
I think NH4Br+H2O2 would do it.
Bromine isn't really too hazardous. It's easy to handle and you can't really get hurt if you kow what your doing.
Nicodem - 9-6-2006 at 09:54
Your question can only be answered by searching Beilstein or SciFinder. The only other way is to experimentally find the conditions for a Hell-Volhard-Zelinsky reaction that would leave the phenyl ring un-brominated. Since the usual reaction conditions are not so harsh I would say it
is possible. Anyway, for details you should search literature references instead of asking in a forum.
Edit: SkyNet, he is not asking about brominating the aromatic ring. Anyway, even if he would, not even Br2 would be good enough without a Lewis acid
so you can be sure NH4Br + H2O2 would not do it.
[Edited on 9-6-2006 by Nicodem]
=SkyNET= - 9-6-2006 at 09:59
D'oh
Thanks