Sciencemadness Discussion Board

Does Reimer-Tiemann reaction only work for phenols?

guy - 17-1-2007 at 16:24

I think the Reimer-Tiemann reaction proceeds by an electrophilic addition of dichlorocarbene to an activated aromatic ring (like phenols), so the question is would it work with other activated rings like toluene or xylene? If not, why?

Ozone - 17-1-2007 at 16:58

Guy,

For your records I have attached a chapter on the Reimer-Tiemann rxn. A section regarding the scope and limitations of the reaction is included therein.

Hope this helps,

O3

Attachment: reimer-tiemann rxn.pdf (1.9MB)
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guy - 17-1-2007 at 21:40

thanks a lot

DraconicAcid - 28-3-2023 at 20:18

Sorry for necromancing this thread, but could the reaction be done on acetaminophen? I can't seem to find the expected product listed anywhere.