Sciencemadness Discussion Board

Nucleic acid synthesis

polymer - 3-5-2007 at 13:28

For a while, I have been wanting to synthesize some DNA bases (Adenine, Guanine, Thymine, Uracil). Can you please suggest a few methods for going about this?

I meant Adenine, guanine, thymine, Cytosine. For some reason, I thought Uracil was a DNA base for a second

[Edited on 3-5-2007 by polymer]

vulture - 3-5-2007 at 13:52

Adenine is possible from HCN and NH3 only. Just need alot of patience.

Sauron - 3-5-2007 at 13:57

I think you mean uridine rather than uracil. Uracil is not a nucleoside; uridine is.

matei - 4-5-2007 at 09:42

These are the classic syntheses of DNA bases:

DNA bases1.bmp - 964kB

Sauron - 4-5-2007 at 09:52

No image is apparent.

matei - 4-5-2007 at 10:01

Sorry, the image seems to be quite big (900 kb or so).

jtkelectroman - 4-5-2007 at 11:21

Quote:
Originally posted by vulture
Adenine is possible from HCN and NH3 only. Just need alot of patience.

I beleive I have a somewhat detailed synthesis of this in a book of mine. The synthesis deals with ring formation from HCN and NH3