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Author: Subject: Denatonium Benzoate synthesis
kazaa81
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cool.gif posted on 18-6-2006 at 07:15
Denatonium Benzoate synthesis


denatonium benzoate, this strange chemical...however, you know it very well! it is added in about every poison chemical substance to prevent ingestion, because of it's extemely bitter taste.

from wikipedia:
[...] Dilutions of as little as 10 ppm are unbearably bitter to most humans [...]

This is surely the compound we would like to synthetize.

Denatonium on wikipedia
http://en.wikipedia.org/wiki/Denatonium

However, the problem is that it is a fairly complicated compound, and even OrgSyn does seem to not have a synthesis for it.
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The_Davster
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[*] posted on 18-6-2006 at 10:28


Here is a scheme, although it starts from lidocaine, so you may want to start off with a synthesis of lidocaine.

Attachment: denatonium benzoate.pdf (77kB)
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Misanthropy
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[*] posted on 30-8-2006 at 14:49


The reverse to this would be more interesting...



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MadHatter
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[*] posted on 30-8-2006 at 21:29
Bitter


That was probably the shit my mother put on my fingernails as a child to deter me from
biting them. Didn't work. I bit them anyway.




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Swany
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[*] posted on 31-8-2006 at 05:33


I found about 100 1.8ml carpules of 2% lidocaine, and will probably be attempting the synthesis soonish.



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