Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: Soxhlet Extraction
Drunkguy
Hazard to Others
***




Posts: 172
Registered: 23-12-2005
Member Is Offline

Mood: somewhat pissed.

[*] posted on 25-2-2008 at 14:15
Soxhlet Extraction


Cant you do small-scale extractions of mimosa hostilis wood bark by Soxhlet extraction?

I've noticed the people extracting the product arent exactly renowned for their rich assortment of glassware.




View user's profile View All Posts By User
contrived
Hazard to Self
**




Posts: 56
Registered: 9-3-2007
Location: Washington State
Member Is Offline

Mood: skeptical

[*] posted on 25-2-2008 at 15:45


Why not use a soxhlet? What's the solvent? What's the quantity? If its really a small amount you could do something we've tried; put your bark and solvent in a flask in an ultra-sound cleaner. Another method is critical fluid extraction with (in this case) CO2. You are after an alkaloid? Yes? CO2.
View user's profile View All Posts By User
jokull
International Hazard
*****




Posts: 502
Registered: 22-2-2006
Location: Everywhere
Member Is Offline

Mood: Ice glassed

[*] posted on 26-2-2008 at 06:41


As contrived said, the ultrasound is a good choice, if you don't have such an apparatus you can use a conventional microwave oven, just have to experiment with power levels and "irradiation" time. I think there is a thread which inclludes a paper on microwave extraction of natural products.
View user's profile View All Posts By User
syntelman
Harmless
*




Posts: 31
Registered: 26-8-2007
Location: Europe
Member Is Offline

Mood: Tired

[*] posted on 26-2-2008 at 08:13


Yes, but considering that the alkaloid content of Mimosa is rather low (although high compared to many other plants) most people are not interested in small-scale extractions. You'll need a pretty large Soxhlet to put 1-2 kg of dry root bark in. Standard A/B extraction works very well, and can yield DMT of pretty decent purity if done correctly.



http://www.blacklight.in - Advanced Drug Chemistry & Pharmacology Discussion
View user's profile View All Posts By User
chemrox
International Hazard
*****




Posts: 2953
Registered: 18-1-2007
Location: UTM
Member Is Offline

Mood: LaGrangian

[*] posted on 26-2-2008 at 23:08


I'm confused. You say standard a/b extraction works pretty well. Bt first you have to get from the solid material to the extractable liquid so there you have some sort of transfer technique. Large volume soxhlets have been made to handle 500g-1kg amounts. I reasd of people making infusions and soaking material in solvents but I think these are wasteful compared with soxhlet or critical fluid.



"When you let the dumbasses vote you end up with populism followed by autocracy and getting back is a bitch." Plato (sort of)
View user's profile View All Posts By User
syntelman
Harmless
*




Posts: 31
Registered: 26-8-2007
Location: Europe
Member Is Offline

Mood: Tired

[*] posted on 27-2-2008 at 04:04


Pulverised root bark defatted by non-polar solvent followed by multiple extractions with dilute hydrochloric acid will soak out a lot of the good stuff. Sure, soxhlet may work better but how much do you pay for a Soxhlet extractor capable of handling 1kg of root bark, compared to a 5L HDPE can? If you have the possibility (which most people interested in DMT hasn't) do it, else just do a standard A/B.

My point is just that A/B works perfectly fine, and most people are not interested in the chemistry or optimization of the extraction techniques by buying lots of expensive glassware. They just go to the hardware store and buy some dirty solvents and follow some tutorial found on Shroomery. And I have seen beautiful DMT crystals produced by that method (and with good yields compared to literature values of alkaloid percentages) :)




http://www.blacklight.in - Advanced Drug Chemistry & Pharmacology Discussion
View user's profile View All Posts By User
Nick F
National Hazard
****




Posts: 439
Registered: 7-9-2002
Member Is Offline

Mood: No Mood

[*] posted on 27-2-2008 at 04:35


Yeah, lit. values seem way too low. I'm a member of the nook because I'm a bit of a cactus nut, and some people there seem to be consistenty getting 2-3x what the lit. says.
View user's profile View All Posts By User
Drunkguy
Hazard to Others
***




Posts: 172
Registered: 23-12-2005
Member Is Offline

Mood: somewhat pissed.

[*] posted on 27-2-2008 at 07:59


Hmm, I dont even have a Soxhlet extractor btw, they arent that important I dont think, other than I recall Shulgin mentioning it in the chemical synthesis of mescaline. Plus, I used it once when we were doing aldol self-condensation of acetone in undergraduate organic practical, to hold the catalyst (BaSO4?).

My question was just concerning the actual principle of doing a plant extraction like this, more so than actually attemtping to do it.

Ofcourse, dmt extraction has been covered numerous times in other places so there is no need to discuss that further here, it is cheeky to have it in the organic chemistry section since it doesnt involve forming covalent bonds.




View user's profile View All Posts By User

  Go To Top