Ritter
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V-agent codes?
Does anyone have a complete list of the V-agents that came out of the ICI insecticide research program in the early 1950s? VG is Amiton and VX is of
course VX. I have found structures for VE, VM, VS & VR ('Russian VX'), but I'm interested in the others. For instance, the V-agent second letter
code for the molecule patented in US2943015. It is claimed to be more potent that VG, a compound by itself that is nasty enough that it is claimed
that the N Koreans have stockpiles of it. (See http://tinyurl.com/4qtu4f).
[Edited on 20-6-2008 by Ritter]
[Edited on 20-6-2008 by Ritter]
Ritter
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\"The production of too many useful things results in too many useless people.\"
Karl Marx
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Sauron
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I do not believe that what you are asking for exists in the open literature, anywhere.
Sic gorgeamus a los subjectatus nunc.
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Ritter
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| Quote: | Originally posted by Sauron
I do not believe that what you are asking for exists in the open literature, anywhere. |
Tucker got some very sensitive (as in Secret) U.S. Army Chemical Corps reports on sarin process chemistry released under the FOIA. As the U.S. traded
nuclear for CW info with the U.K. in the late 1950s, the list of V-agents from which VX was ultimately selected is probably locked up in a file
cabinet in Edgewood. I'd file a FOIA request but with all this WMD hysteria since 9/11 I'd likely get both the information (heavily redacted, no
doubt) & my name on a list at FBI HQ. I'm not writing a book on CW, so I'll let this one rest!
Ritter
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\"The production of too many useful things results in too many useless people.\"
Karl Marx
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Sauron
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The special category of security classification is called CNWDI which stands for Chemical and Nuclear Weapons Design Information. A special clearance
is required, which is to say, someone with an ordinary TS is not permitted to root around in this data.
As you are doubtless aware the crux of the V-agent SAR is the aminoethylthiol ester side chain and as any medicinal chemist will tell you, why is no
mystery. It is the choline skeleton. In this case, thiated. This imparts the particular lock and key docking to cholinergic receptor sites and the
nonbonded electrons on N and S are the hooks. The S also imparts lipophilicity, hence skin permeability, and the P-S bond is not very labile so the
agent is persistant (relative to G-agents.) Hence an area denial weapon.
It is interesting to note that the O-ester is a primary one. In the G-series, it was the secondary O-esters that imparted the greatest toxicity, at
least in concert with a fluorine moiety. Hence O-2-propyl is more potent that O-ethyl. O-pinacolyl is hindered so is less labile to hydrolysis than
isopropyl, which is why GD is semipersistant.
Sic gorgeamus a los subjectatus nunc.
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NovichokVX
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i know exist Ve , VG , VM , R , Vs and VX , but , exist other V and G agents ?! 
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