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CuReUS
National Hazard
Posts: 928
Registered: 9-9-2014
Member Is Offline
Mood: No Mood
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I have good news and bad news.
the good news is that phenyl benzamides can be rearranged to amino benzophenones via a fries reaction.
the bad news is that the ref is not online - Ravi, Subban; Saravanan, Nagusamy; Shanthi, Andy; Dharmaraj, Nallusamy; Lakshmanan, Akoni J Indian
Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 4 p. 443 - 445 (83% yield)
another paper from the same authors - http://nopr.niscair.res.in/bitstream/123456789/8970/1/IJCB%2...
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Chemi Pharma
Hazard to Others
Posts: 349
Registered: 5-5-2016
Location: Latin America
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Hi @jmister28,
I agree with other members that thinks you want to synthesize benzos, but it's not my business at all make you questions about that, cause I'm only
interested in the chemical reactions.
What can I do for you? at your other thread you ask members from the Sciencemadness how to sinthesize 2-bromobenzoyl chloride. I've already posted at
that thread how you can achive this chemical from salicylic acid. Look here: http://www.sciencemadness.org/talk/viewthread.php?tid=114280... and here: http://www.sciencemadness.org/talk/viewthread.php?tid=114280...
As you can see in that links, you don't need the nasty SOCl2 at all to do this reactions, like some members said.
To do the condensation beetween chloro-benzoyl chloride and 4-chloro aniline with ZnCl2, I have two ilustrative papers to give to you, I'm attaching
below.
Don't forget you have two common ways to close the benzodiazepinic ring: one using chloroacetyl chloride, and I have a good and easy sinthesis for it,
that I'm attaching too. Other way is using glycine ethyl ester hydrochloride.
But this is another step and I will reserve to me the right opportunity to bring the right papers for this synthesis here in Sciencemadness anytime in
the future.
Attachment: chloroacetyl chloride from trichloethylene, chloroacetic acid and p-tolueno sulfonic acid.pdf (361kB)
This file has been downloaded 263 times
Attachment: 2-amino-5-chlorobenzophenone.pdf (676kB)
This file has been downloaded 313 times
Attachment: 2-amino-5-chlorobenzophenone II.pdf (269kB)
This file has been downloaded 294 times
[Edited on 27-12-2018 by Chemi Pharma]
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