ItalianXKem
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Simvastatin farmaceutical industrial synthesis ?
what is the simvastatin's synthesis ?
is a medicine , is on gruop of statin (statines)
http://en.wikipedia.org/wiki/Simvastatin
for what is used ?
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Ebao-lu
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Simvastatin is synthesised from lovastatin http://en.wikipedia.org/wiki/Lovastatin(that is naturally present in some fungi), by adding of a methyl
group.. I dont know which method is now mostly used in industry, but probably it is biocatalitical
Statins inhibit the rate-limiting step of cholestrol biosynthesis by binding to HMG-CoA reductase, and mostly used for treatment and prophylaxis of
coronary heart disease. They reduce the level of low density lipoproteins and are believed to reduce the cholesterol atherosclerotic plaques, or at
least prevent existing ones from growth. These plaques tend to form in vessles, if the cholesterol levels are high, and when they grow big enough,
they can reduce the blood flow in that place, and even come off of the vascular wall into a blood flow and plug some vessels. This leads to
unsufficient blood supply of myocard(ischemia), infarcts and strokes.
Statins are known to reduce these things occurance.
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Sauron
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[8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl] -3,7-dimethyl-1,2,3,7,8,8a- hexahydronaphthalen- 1-yl] 2-methylbutanoate
is the IUPAC name for the parent compound lovaststin
Sic gorgeamus a los subjectatus nunc.
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ItalianXKem
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thkx  ; i see , has a suspect salvinorin like structure
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Ebao-lu
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and you probably want to play with the molecule of simvastatin to make it KOR-agonist, right ?
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ItalianXKem
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I saw now that the structure of simvastatin is similar to that of cannabinoids , salvinorins (much Salvinorin A) and many other example some of
quaternary ammonium muscle relaxant
http://en.wikipedia.org/wiki/File:Simvastatin.svg
http://en.wikipedia.org/wiki/File:Salvinorin-A_structure.png
http://en.wikipedia.org/wiki/Category:Cannabinoids
http://en.wikipedia.org/wiki/Cannabinoids
http://en.wikipedia.org/wiki/Quaternary_ammonium_muscle_rela...
salivinorin A is very like structure to simvastatin
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Nicodem
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| Quote: | Originally posted by ItalianXKem
salivinorin A is very like structure to simvastatin |
You must be joking! Then just about every organic compound has a structure similar to just about any other organic compound. So what would be the
point of researching organic chemistry if everything is alike.
Stop posting nonsense, trolling, or whatever you are trying to do. Rather spend your time studying. Instead of wasting time online, go to a library.
I'm moving this thread to Beginnings since it became no more than an attempt to teach the basics.
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Ebao-lu
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Yes, in theory there is some possibility that modification of simvastatin structure can give a KOR agonist. But you'll not find the key structure or
die tryin'. There are no computer programs to sustainably calculate the structure-activity correlations, and any small change in the molecule can be
critical.
If you want to make salvinorin from simvastatin, the only route i can suggest you is: burn simvastatin in oxygen to CO2, and then grow salvia
divinorum using this CO2 as a source of carbon.
[Edited on 17-12-2008 by Ebao-lu]
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