Nixie
Hazard to Others
Posts: 490
Registered: 12-12-2006
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Mood: ?
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Fluorouracil synthesis?
I have had some knuckle pads for around two years now, and the dermatologist said there is no effective treatment (knuckle pads are a keratodermal
thickening of the skin at finger joint positions without established cause). They're not disabling but uncomfortable and if I don't bite them or file
them down, they tend to grow further and eventually crack, which can be painful or bleeding.
I have read a recent paper about a promising treatment option using fluorouracil ( http://archderm.ama-assn.org/cgi/content/extract/143/11/1458 ), but this is still too new and even if I convince the dermatologist to do it, there
is no way my medical coverage would pay for it, and there is no way I can afford it at this point or in the near future. Thus, I would like to
synthesize it, and I'm asking for help here as to how to go about that. I normally have access to only OTC substances, but with some effort and risk
might be able to acquire other reagents.
\"Good is a product of the ethical and spiritual artistry of individuals; it cannot be mass-produced.\" --Aldous Huxley
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Ozonelabs
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Posts: 120
Registered: 5-4-2008
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Mood: Oligomerised
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Perhaps this will be of some use to you:
http://www.ualberta.ca/~csps/JPPS10_2/8/final.pdf
Found with just a few moments using google. I shall consult with my lab partner on this synthesis to see whether we have immediately available the
required chemicals to conduct this procedure.
Ozonelabs
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stoichiometric_steve
National Hazard
Posts: 819
Registered: 14-12-2005
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Mood: satyric
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Put the effort into buying the real thing. Yet, the ingestion of the raw material would be a violation of certain laws i guess.
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Nixie
Hazard to Others
Posts: 490
Registered: 12-12-2006
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Mood: ?
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Pardon? You do not ingest it--you put it in the affected skin area.
The only affordable I see is very low concentration cream. Assuming I can find an online pharmacy that will ship to Canada without prescription (and
I haven't yet), I'd still need a way to extract the substance from the cream, as the application described in the paper referenced is intralesional,
not topical.
Ozone, kindly let me know what you find out.
\"Good is a product of the ethical and spiritual artistry of individuals; it cannot be mass-produced.\" --Aldous Huxley
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