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Author: Subject: can Meth be made without pseudoephedrine?
JohnWW
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[*] posted on 10-10-2009 at 08:04


Quote: Originally posted by Mossydie  
Beyond the economic problems, surely there's an argument that the government should do everything in its power to eradicate Meth production on moral grounds?

No! Ever since the Prohibition era of alcohol of the 1920s, which merely served to enrich a few smugglers, bootleggers, moonshiners, slygroggers, and the proprietors of "speakeasys" (illegal pubs), it has been clear that banning various drug substances merely creates blackmarkets for them. This, due to the public perception of shortages of the substances, and resulting steep price rises for them, can be exploited by the criminal element in supplying them, which began with the millionaire gangsters of the 1920s, such as Al Capone, Legs Diamond (Jack Moran), Pretty Boy Floyd, Baby Face Nelson, Dutch Schultz, Bugs Moran, and the rest. It culminated in the infamous Valentine's Day Massacre of Bugs Moran's gang by Al Capone's, on 14th Feb. 1929 in Chicago, Il.

Serious drug addiction and consequent criminal involvement was never a problem when for centuries, until about the 1930s, one could go down to the local drugstore, and buy any amount of heroin, morphine, cocaine, marijuana, hashish, barbiturates, and amphetamines, over-the-counter with no questions or prescriptions, often in attractive richly-decorated packaging. Heroin was widely advertized by manufacturing chemists as being "the perfect guardian of health", and a cure-all.

If drugs were legal, their prices would be so low that it would not be worthwhile for criminals to get involved in blackmarketing them, blackmarket (non-pharmacy) supplies of them would be minimal, and any addicts (who would be much fewer) would be more willing to come forward for treatment. Because drugs would then be much less in the news media, there would be much fewer people trying them out as novelties. Many people have the philosophy that, if something is made illegal by the government, it must be good for you, and so try illegal drugs either out of curiosity or as an act of defiance of the $tate.

[Edited on 10-10-09 by JohnWW]
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Magpie
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[*] posted on 10-10-2009 at 08:05


Thank you watson and entropy. I certainly have been educated. I can understand that there would be significant organo-phosphorus contamination. This is the basis for many insecticides.

Actually, this is one of the reasons I don't like to use motels much anymore.




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S.C. Wack
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[*] posted on 10-10-2009 at 08:53


The links are typical, methamphetamine base itself being what is targeted. Since we are in an age where we can detect very very very low levels of things like meth, getting to a level like below 10 micrograms per square meter is rather challenging.

However, this meth residue has less to do with the manufacture of meth than from the smoking of it by the operators. It's convenient to say it's from the evil meth cooks and their sinister chemistry.
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watson.fawkes
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[*] posted on 10-10-2009 at 09:10


Quote: Originally posted by entropy51  
Link to NY Times article about a contaminated home
Thanks for that. Here's an excerpt germane to the question of politics of changing drug laws:
Quote:
About 20 states have passed laws requiring meth contamination cleanup, and they use widely varied standards. Virtually all the laws hold the property owner financially responsible; Colorado appears to be the only state that allots federal grant money to help innocent property owners faced with unexpected cleanup jobs.

In other states, like Georgia, landlords and other real estate owners have fought a proposed cleanup law.
Property owners have a class interest in reducing the amount of money they have to pay for cleaning up. They can try to foist off costs on someone else; this is the Georgia example. Beyond the immediate scope of the article, though, consider how that same class of property owners would respond to a proposed law decriminalizing meth production. Such a law would cost them money and they'll oppose it.

Generalizing further, there's no _a priori_ reason why there won't be "home chemistry research lab clean up" somewhere in the future. Perfectly legal research, when performed sloppily, can generate just as much toxicity, perhaps more.

Here's another excerpt from that article:
Quote:
To Ms. Holt’s horror, inspectors found high concentrations of meth on her kitchen countertops, where she sterilized bottles, prepared baby food and doled out snacks.
The assays for contaminants focus on the illegal substances themselves, since that's the evidence in court that law enforcement is interested in. So there's an observation bias in favor of specific contraband substances and against all other byproducts of synthesis. So whenever I read "meth was found", I have to wonder exactly what else is actually there. The various symptoms I've read about don't seem to me to be caused solely by methamphetamine as such (although it's certainly possible they are).
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entropy51
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[*] posted on 10-10-2009 at 09:27


Quote:
The various symptoms I've read about don't seem to me to be caused solely by methamphetamine as such (although it's certainly possible they are).


Probably not by pure product, but the illicit stuff is never pure.

Quote:
Generalizing further, there's no _a priori_ reason why there won't be "home chemistry research lab clean up" somewhere in the future. Perfectly legal research, when performed sloppily, can generate just as much toxicity, perhaps more.


There already is! Recall the threads here about the hapless Mr. Deeb in Massachusetts. I think the real risk to many of us (but not all - you know who you are) is not being brought up on drug charges, but rather being charged 200 K US$ for "environmental cleanup" of our labs.

If you read the court transcripts in drug lab cases, you see that the court recognizes narc squad officers as "experts" and they give testimony to the effect that the whole place is contaminated with "biohazards" because there was a bottle of HCl under the sink. I posted a link to one of these transcripts back in June. Interesting and scary reading.
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watson.fawkes
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[*] posted on 10-10-2009 at 10:07


Quote: Originally posted by entropy51  
There already is! Recall the threads here about the hapless Mr. Deeb in Massachusetts.
Granted, but what I was really talking about was actual contamination by a non-property owner, neither satisfied in the Deeb case, whose "clean up" is a jurisdiction covering its own ass.
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[*] posted on 10-10-2009 at 10:56


It is quite obvious that certain groups profit enormously from keeping you constantly brainwashed and frightened with the demons that are everywhere and ought to destroy you. Illegal (i.e certain) drugs are one of those demons (but of course when Pfizer sells those same compounds they are angels). Others such demons are indians, blacks, russians, homosexuals, nicaraguans, communists, list can be very long. It is an old and very effective trick used by few to control many, and also to relocate the public resources into a few private pockets. More demons = less freedom. Enjoy.

[Edited on 10-10-2009 by Sandmeyer]




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[*] posted on 10-10-2009 at 13:20


Quote: Originally posted by JohnWW  

No! Ever since the Prohibition era of alcohol of the 1920s, which merely served to enrich a few smugglers, bootleggers, moonshiners, slygroggers, and the proprietors of "speakeasys" (illegal pubs), it has been clear that banning various drug substances merely creates blackmarkets for them. This, due to the public perception of shortages of the substances, and resulting steep price rises for them, can be exploited by the criminal element in supplying them, which began with the millionaire gangsters of the 1920s, such as Al Capone, Legs Diamond, Pretty Boy Floyd, and the rest.


Yes, but regardless of the effects of making substances illegal or attempting to stop their production, (which I agree often prevent a good case for legalization) assuming one thinks that the substance will have only a negative on users and society then one would be morally obligated to do everything possible to try to get rid of it. An analogy could run along the lines that if you know someone is out to kill someone else and you have an opportunity to take away their gun then you would probably do so, even if this potentially leads to them suffering a far more violent death at the hands of a crude implement.

But this is a chemistry forum - Molarity, not Morality, I apologise for raising the topic.
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hissingnoise
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[*] posted on 11-10-2009 at 04:10


Quote: Originally posted by Mossydie  
An analogy could run along the lines that if you know someone is out to kill someone else and you have an opportunity to take away their gun then you would probably do so, even if this potentially leads to them suffering a far more violent death at the hands of a crude implement.

That's quite a good analogy, Mossydie; it seems to sum up anti-drug measures very neatly. . .
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Sandmeyer
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[*] posted on 11-10-2009 at 04:59


Quote: Originally posted by Mossydie  


Yes, but regardless of the effects of making substances illegal or attempting to stop their production, (which I agree often prevent a good case for legalization) assuming one thinks that the substance will have only a negative on users and society then one would be morally obligated to do everything possible to try to get rid of it. An analogy could run along the lines that if you know someone is out to kill someone else and you have an opportunity to take away their gun then you would probably do so, even if this potentially leads to them suffering a far more violent death at the hands of a crude implement.


Well, a much better analogy would be alcohol and nicotine. Where are the "moral obligations" to criminalize them? What truly is immoral (or should be in a reasonable society) is when The State makes it illegal for the individual to dock certain ligands into his own receptors. That's tyranny and is no different from criminalizing the act of preciving certain colors or smells.




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[*] posted on 11-10-2009 at 05:14


Alcohol and nicotine doesn't provide an analogy...

The issue with these is that they are too ingrained into culture. We're past the point at which they could be eradicated because the majority of the population would be against that - no politician would ever do anything that would loose such large numbers of voters. But in the case of the other drugs, luckily enough we're not at the stage where they can't be wiped out, and clearly the majority of the population feels it's a good thing to try to eradicate them.
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[*] posted on 11-10-2009 at 05:37


Quote:
Alcohol and nicotine doesn't provide an analogy...


Yes they do.

Quote:
The issue with these is that they are too ingrained into culture.


That's not even an argument. Culture? Do you meen apple pie and baseball? Besides, why would your "culture" decide what is legal or not for someone else to dock into his receptors? Sounds absurd.

Quote:
We're past the point at which they could be eradicated because the majority of the population would be against that - no politician would ever do anything that would loose such large numbers of voters.


Vast majority of the population is against the war - but wars there are. The population are the outsiders, for all practical purposes they have no say in the shapings of the policies that affects their lifes. So, no that argument isn't valid either, the state can criminalize without population liking the legislation, the file-sharing-copyright issue is one of many such examples. In state-capitalist society the state is owned and used as an instrument by mega corporations for their own private interests. Financial corporation bailout is one recent example, people didn't like it but who cares? Thst's the reality, by the people for the people is a comfortable illusion.

[Edited on 11-10-2009 by Sandmeyer]




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[*] posted on 11-10-2009 at 06:03


This is an interesting patent. Phenylpropanolamine used to be OTC in the US, but isn't any more. Maybe another hydrogenation method could be used, ie. CTH.

US 2243295 Phenylpropanolamine and HCOH hydrogenated (Ni catalyst) to produce phenylisopropylmethylamine

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Vogelzang
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[*] posted on 11-10-2009 at 06:06


More patents.

2146473 Methylation of phenylisopropylamine, 1) using methyl iodide on benzaldehyde Schiff base, and 2) using HCOH and activated Al

2146474 Para hydroxy P2P, alcohol, 40% aqueous CH3NH2, reduction using activated Al turnings

2414031 Nitromethane + aldehyde + PtO catalyst --> secondary amine

2700682 Ketimine reduction, example 1: P2P, CH3NH2, KOH drying agent, example 2: catalytic reduction using Pd/C

2828343 P2P + CH3NH2 reduction using cupric oxide catalyst

3925475 P2P-like imines reduced with NaBH4



[Edited on 11-10-2009 by Vogelzang]
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[*] posted on 11-10-2009 at 06:10


You seem to misunderstand - I simply argued that as these drugs can be eradicated then every effort should be made to achieve that, EVEN IF it might be futile in the long run.

But hang on - you weren't the guy I had a similar argument with over a youtube video were you?
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Vogelzang
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[*] posted on 11-10-2009 at 06:12


2011790 p-MeO-P2P aminated with MeNH3Cl + NaOOCH (example 4)

2205530 2MeO-P2P, activated Al turnings, ether, 40% MeNH2 refluxed 6 hours

2382686 4Me-P2P from Me-C6H6CH2CN + EtOAc using Na in EtOH, 4Me-P2P aminated with MeNH2 using Ni catalyst and H2 at several atmospheres and 90-100º C

5220068 1,3-diphenylacetone (example 5), 96% EtOH, n-propylamine, Al foils(Hg)

http://www.pat2pdf.org
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hissingnoise
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[*] posted on 11-10-2009 at 06:15


Quote: Originally posted by Mossydie  
But in the case of the other drugs, luckily enough we're not at the stage where they can't be wiped out, and clearly the majority of the population feels it's a good thing to try to eradicate them.

And paradoxically, all efforts at eradication have had the opposite effect.
The most dangerous drugs have been glamourised by prohibition. . .
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entropy51
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[*] posted on 11-10-2009 at 06:42


Quote: Originally posted by Vogelzang  
More patents.


Chemporn for people who have neither chemicals nor glassware. Drooling over all the ways they could get laid if they just had a 3 neck flask.:P
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[*] posted on 12-10-2009 at 06:55


Vicks inhalers contain l-methamphetamine aka levfetamine, levo-methaphetamine, or l-desoxyephedrine. You should be able to convert it into the racemic form using these processes:

US 2608583 Method for stereo-chemical equilibration of secondary carbinamines

US 2797243 Improved method for converting l-amphetamine into d-l-amphetamine

http://ep.espacenet.com/numberSearch

http://www.pat2pdf.org
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[*] posted on 12-10-2009 at 09:17


The original question has been answered, and the recent discussion seems none too encouraging.



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Polverone
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