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medchem
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Drug discovery related informations
hello everybody,
I have started this thread to provide the updates about the drug discovery related informations (from my blog). Hope to see your feedback so that it
will be helpful to improve my site.
[Edited on 12-12-2009 by medchem]
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kclo4
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Very nice blog! I like it, thanks for taking the time and effort. 
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medchem
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@kclo4, thank you so much for your feedback. It's nice to see indiescience as your signature (I am familiar to..).
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Picric-A
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Awsome blog medchem! i Especially like the page of Baloon hydrogenation, awsome vid!
Thanks!
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stateofhack
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Very nice, your hydrogenation information is very nice!
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medchem
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@picric-A, stateofhack. Thank you so much.
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marksev1
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Very nice just in my field of study... your blog is going into my bookmarks, keep up the good work..
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medchem
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@marksev1, thanks a lot for a bookmark (or you can subscribe at alert for new post, if you want
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medchem
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Recently, ritonavir (antiretroviral) has been reported to show anticancer effect. Check out more informations .......<a
href="http://medchemblog.blogspot.com/2009/12/exploration-of-old-drugs-for-new.html">exploration of ritonavir as anticancer agent</a>
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Formatik
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It looks nice. There are so many possibilities for discussion since there are always new discoveries being made in this field. I was recently reading
about anti-aging effects of aminoguanidine (interesting compound which also appeared in some discussions here).
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medchem
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thanks formatik. and aminoguanidine looks interesting. It's used as antidiabetic rite? I tried to search but couldnt grab the enough references
regarding its clinical use for different pharmacological activity. If you do have would you please let me know?
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Formatik
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Yeah, sure. There's this article, which also has references at the bottom of it: http://www.smart-drugs.net/ias-aminoguanidine.htm
Also, search PubMed for "AGE" and aminoguanidine, this yields many studies, e.g.
Exp Gerontol. 2008 Jun;43(6):584-8.
Reconstructed skin modified by glycation of the dermal equivalent as a model for skin aging and its potential use to evaluate anti-glycation
molecules.
Pageon H, Técher MP, Asselineau D.
anti-tumor action of aminoguanidine:
World J Gastroenterol. 2009 Mar 7;15(9):1065-71.
Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice.
Mohamad NA, Cricco GP, Sambuco LA, Croci M, Medina VA, Gutiérrez AS, Bergoc RM, Rivera ES, Martín GA.
[Edited on 21-12-2009 by Formatik]
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kclo4
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You would be interested in the ImmInst forum...
http://www.imminst.org/
I think the people there would also enjoy your blog.
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medchem
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thanks a lot
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medchem
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Salen ligand are popular ligands because of their easy formation and rich coordination chemistry with large variety of metal ions, and being used as
catalysts in different asymmetric reactions. Recently a novel <a
href="http://medchemblog.blogspot.com/2009/12/metal-complexes-of-salen-ligand-bearing.html">metal-salen complexes bearing Ferrocenophane
has been synthesized</a>
N I wish all sciencemadness users a very very happy new year 2010!!
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medchem
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cyclic anti HIV peptide
Human theta defensin genes are present in human but presence of premature stop codon blocks the translation. Correction of these genes with
aminoglycosides activate genes to produce theta defensin, a cyclic anti HIV peptide.
<a href="http://medchemblog.blogspot.com/2010/01/reawakening-of-human-theta-defensins.html">aminoglycosides for reawakening of retrocylins for
anti HIV-1</a>
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medchem
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thiophene-oxadiazole core has been found to be important for HIF-I inhibitory activity. As we know HIF-I has key role in transcription of various
genes involved in cell growth and survival, the mentioned core may provide a new insight to researchers for the development of anticancer agents.
If your are interested, please check out my blog and hope to see some informations related to the topic in comment section (YOUR view is important
)
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kclo4
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What did you think of the Imminst forums?
I'm just curious.. it is a weird place.
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medchem
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Ya everything looks cool and even subject criteria is broad which is good to involve a large number of audience. I am trying to involve in disease and
medicine section.
"The motto of the site is interesting and weird too."
So, what's your view? which section do you like the most?
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medchem
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hello guys,
I have posted simple method of recording TLC data in my blog. Would you plz check and give your feedback. Sharing your own method in the comment
section will be great.
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medchem
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Proton pump inhibitors like omeprazole and pantoprazole has been studied for anti-allergic asthmatic activity. please check out the latest update in
the blog with animated clip about MOA of proton pump inhibitors
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Paddywhacker
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Quote: Originally posted by medchem  | hello guys,
I have posted simple method of recording TLC data in my blog. Would you plz check and give your feedback. Sharing your own method in the comment
section will be great.
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Blog comments doesn't allow pics, AFAICS
I keep a hardcopy notebook, but transfer the notes to computer, so photographing and annotating works for me.
eg.
[Edited on 23-1-2010 by Paddywhacker]
[Edited on 23-1-2010 by Paddywhacker]
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medchem
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Paddywhacker: ya image is not allowed in the comment (technical prob). But comments with words are always welcome
recently one of my junior asked about dropping funnel.
here also someone was asking about it.
thinking to make them aware of dropping funnel I have written post about this equipment in my blog with image. I hope it will be helpful for them and
others.......
[Edited on 28-1-2010 by medchem]
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medchem
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Sorafenib; anticancer drug for kidney, lung and liver carcinoma has been found effective against Osteosarcoma.
Please check out the details.
<a href="http://medchemblog.blogspot.com/2010/02/promising-activity-of-sorafenib-as.html">Sorafenib vs Osteosarcoma</a>
And guys, there is one picture showing someone's statue in this post. I guess most of you know whose statue is that? Want to try, plz check out and
mentioned the name of the person in the comment section of the linked blog.
Let's see how many of you know that person?
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medchem
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<a href="http://medchemblog.blogspot.com/2010/02/photo-degradation-of-rofecoxib-cox-2.html">It is found that Rofecoxib is photocyclized to give
new product as 6-methylsulphonylphenanthro[9, 10-C]-furan-1(3H)one.</a>
I hope to see your view on the proposed degradation mechanism.
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