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Author: Subject: Drug discovery related informations
medchem
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[*] posted on 18-2-2010 at 07:45


<a href="http://medchemblog.blogspot.com/2010/02/silver-nanoparticles-against-hiv-1.html">Recent finding shows that silver nanoparticles has potential to inhibit hiv-1 entry by binding to gp120.</a>



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[*] posted on 20-3-2010 at 00:13


It has been quite busy weeks...after long gap, I have posted <a href="http://medchemblog.blogspot.com/2010/03/neuroprotective-and-antioxidant-effects.html">about pramipexole enantiomers and its antioxidant activity</a>. Check it out!



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[*] posted on 21-3-2010 at 21:57


Regardign pramipoxole

If those compounds are 'anti-oxidants', what consequence is their stereochemistry? I think it's plain as day to see why they're 'active' in that neural cell assay. I would bet thiourea would perform equally well. The isothiourea (thiazole) is likely reducing the peroxide, and it's possible the amine is also being oxidized to the N-oxide. Does the paper suggest otherwise? As far as treating Parkinson's disease effectively by acting as a dopaminergic... I wish I could agree, Parkinson's is a truly mysterious condition. Medicinal chemistry still has its work cut out in that department.

Say, do you have any experience with AutoDock?
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[*] posted on 25-3-2010 at 19:00


Permeability transition pore (PTP) as a possible target of this drug
It is already reported that pramipexole can enter and accumulate in mitochondira. It inhibits the PTP and eliminates the Ca++-triggered swelling thereby preventing the cell death.





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[*] posted on 2-5-2010 at 04:42


Hello everybody (sciencemadness members)
Medchemblog has conducted poll for the best blog....
Medchemblog like and appreciate your participation on the poll.
I am sure most of you are following some of the mentioned blogs...
Please visit MEDCHEMBLOG and give your view.






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[*] posted on 17-5-2010 at 20:49


<a href="http://medchemblog.blogspot.com/2010/05/voreloxin-dna-intercalating.html#more">Anticancer activity of Voreloxin</a>

You can share informations about the voreloxin, pharmacological or chemistry aspects.







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