overunity33
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Ethyl formate MDA>MDMA
interested in Shulgins MDA>MDMA
| Quote: |
Holding at reflux for 16 h a solution of 10 g of MDA as the free base in 20 mL fresh ethyl formate. Removal of the volatiles yielded an oil that set
up to white crystals, weighing 7.8 g. (MDMA freebase) |
Anyone have any advice, information on this?
What about a synthesis for ethyl formate? Will formic acid+ethanol work? What are the reaction parameters?
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Nicodem
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That is a formylation and not a methylation. The product is therefore the corresponding N-alkylformamide, that is
N-(1-(benzo[d][1,3]dioxol-5-yl)propan-2-yl)formamide.
PS: If you refuse to use references, open threads in the Beginnings section where this is moved. Also because, if you would have read the original
reference (PiHKAL #MDMA) you would have realized that it is about formylation by yourself rather than bothering others.
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Nicodem
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Thread Moved
29-4-2010 at 01:16 |
not_important
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And a minute or so of Internet searching gives
A treatise on chemistry, Volume 3, Part 1
By Henry Enfield Roscoe, Carl Schorlemmer
| Quote: | A still more simple method is to heat anhydrous glycerin with equal molecules of alcohol and oxalic acid, connecting the flask with a reversed
condenser until complete decomposition has occurred ; the oxalic acid then requires to be warmed and the ether distils over. The distillate obtained
according to one or other of these methods is shaken up with milk of lime in order to remove free acid, and then dried over chloride of calcium and
rectified.
According to Dittmar the product thus obtained is, however, not quite pure. In order to remove the impurities it must be warmed for some time with
anhydrous copper sulphate and then distilled. |
Other possibly useful references
http://www.archive.org/details/practicaltreatis00deitrich
http://www.archive.org/details/alcoholitsproduc00simmuoft
and two modern ones:
http://www.springerlink.com/content/n6wr58333825756w/
http://dx.doi.org/10.1016/S0926-860X(98)00345-7
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