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Author: Subject: Zolpidem impurity
text0r
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[*] posted on 6-4-2019 at 21:08
Zolpidem impurity


Hello fellas,

Recently I have been find interested building block which someone selling on ebay probably is zolpidem impurity ?

https://www.ebay.com/itm/143190561762

Anyone know this seller is legit ?

Many thanks !
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j_sum1
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[*] posted on 6-4-2019 at 21:47


What kind of building block are you wanting? What is your target compound?
This smells like cookery to me.


If this is a genuine chemistry project then I am sure you will find folks here to be helpful.
Zolpidem has been designed to target very specific biological systems, and is a schedule IV controlled substance. (It does have significant side-effects and acts as a GABA agonist.) I am wondering what legitimate use you could possibly have for it.


I would be wary of buying any unprocessed pharmaceuticals via eBay. I think there is a high risk of not getting what you want or having who-knows-what kind of impurities. What analytical equipment do you have at your disposal?

I have no experience of this particular seller: I don't recall ever ordering anything from Slovenia.
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text0r
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[*] posted on 7-4-2019 at 00:40


Thanks for your reply j_sum1.

We are trying to synthesis the following compound
N-(adamantan-1-yl)-2-[2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

We want to bond Adamantan-1-amine and later Diamantane ring to carboxylic group with eg. DCC, CDI coupling reagent with coupling rxn.

That's why I was asking if anyone ordered already any compounds from that seller.

Thanks.
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sporemaster
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[*] posted on 12-4-2019 at 21:04


All what I can confirm is that I bought from this seller on ebay Propiophenone, and can confirm this vendor is pro. Althrought is a bit expensive but worth it. I havent bought from him this Zolpidem impurity.

if you react this mentioned Zolpidem impurity with dimethylamine you have Zolpidem in high yields >80% if you properly do it. lol

zum.jpg - 97kB
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Tsjerk
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[*] posted on 12-4-2019 at 23:42


Maybe the name of this topic should be changed into "zolpidem precursor".
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DavidJR
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[*] posted on 13-4-2019 at 02:54


Quote: Originally posted by sporemaster  

if you react this mentioned Zolpidem impurity with dimethylamine you have Zolpidem in high yields >80% if you properly do it. lol


Wouldn't you have to first convert the carboxylic acid group to an acyl halide? For example, using thionyl chloride.
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laserlisa
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[*] posted on 13-4-2019 at 03:56


You can amidate the carboxylic acid directly using a petide coupling reagent.
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sporemaster
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[*] posted on 13-4-2019 at 03:59


Hey DavidJR

You dont need first to convert it to acyhalide.

isnt more comortable to form amide from carboxylic acid and amine? with coupling reagent like PyBOP, DCC, CDI, HOBt etc...As mentioned user text0r
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sporemaster
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[*] posted on 13-4-2019 at 04:08


laserlisa :

You took my words :) and with coupling reactions there are high yield without loss. In case if you convert it to acyhalide yield drops drastically + purifyiing etc.... Plus acyhalides are nasty and hard to find. :)
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[*] posted on 13-4-2019 at 08:12


Are coupling agents any easier to find? :-)
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sporemaster
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[*] posted on 13-4-2019 at 09:13


Pomukli:

I have find several suppliers on ebay for example PyBOP but in my opinion is easier to find them than acylhalides which are hazardous chemicals and hard to ship with USPS network :) just my opinion maybe im wrong :)

but coupling reagent are a bit expensive :\

https://www.ebay.com/sch/i.html?_from=R40&_trksid=m570.l...

http://www.commonorganicchemistry.com/Rxn_Pages/Amine_to_Ami...

high yields :)

[Edited on 13-4-2019 by sporemaster]
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