text0r
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Zolpidem impurity
Hello fellas,
Recently I have been find interested building block which someone selling on ebay probably is zolpidem impurity ?
https://www.ebay.com/itm/143190561762
Anyone know this seller is legit ?
Many thanks !
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j_sum1
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What kind of building block are you wanting? What is your target compound?
This smells like cookery to me.
If this is a genuine chemistry project then I am sure you will find folks here to be helpful.
Zolpidem has been designed to target very specific biological systems, and is a schedule IV controlled substance. (It does have significant
side-effects and acts as a GABA agonist.) I am wondering what legitimate use you could possibly have for it.
I would be wary of buying any unprocessed pharmaceuticals via eBay. I think there is a high risk of not getting what you want or having
who-knows-what kind of impurities. What analytical equipment do you have at your disposal?
I have no experience of this particular seller: I don't recall ever ordering anything from Slovenia.
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text0r
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Thanks for your reply j_sum1.
We are trying to synthesis the following compound
N-(adamantan-1-yl)-2-[2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
We want to bond Adamantan-1-amine and later Diamantane ring to carboxylic group with eg. DCC, CDI coupling reagent with coupling rxn.
That's why I was asking if anyone ordered already any compounds from that seller.
Thanks.
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sporemaster
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All what I can confirm is that I bought from this seller on ebay Propiophenone, and can confirm this vendor is pro. Althrought is a bit expensive but
worth it. I havent bought from him this Zolpidem impurity.
if you react this mentioned Zolpidem impurity with dimethylamine you have Zolpidem in high yields >80% if you properly do it. lol
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Tsjerk
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Maybe the name of this topic should be changed into "zolpidem precursor".
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DavidJR
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Quote: Originally posted by sporemaster  |
if you react this mentioned Zolpidem impurity with dimethylamine you have Zolpidem in high yields >80% if you properly do it. lol
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Wouldn't you have to first convert the carboxylic acid group to an acyl halide? For example, using thionyl chloride.
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laserlisa
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You can amidate the carboxylic acid directly using a petide coupling reagent.
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sporemaster
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Hey DavidJR
You dont need first to convert it to acyhalide.
isnt more comortable to form amide from carboxylic acid and amine? with coupling reagent like PyBOP, DCC, CDI, HOBt etc...As mentioned user text0r
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sporemaster
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laserlisa :
You took my words  and with coupling reactions there are high yield without loss.
In case if you convert it to acyhalide yield drops drastically + purifyiing etc.... Plus acyhalides are nasty and hard to find.
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Pumukli
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Are coupling agents any easier to find? :-)
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sporemaster
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Pomukli:
I have find several suppliers on ebay for example PyBOP but in my opinion is easier to find them than acylhalides which are hazardous chemicals and
hard to ship with USPS network just my opinion maybe im wrong
but coupling reagent are a bit expensive :\
https://www.ebay.com/sch/i.html?_from=R40&_trksid=m570.l...
http://www.commonorganicchemistry.com/Rxn_Pages/Amine_to_Ami...
high yields
[Edited on 13-4-2019 by sporemaster]
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