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Author: Subject: 10 most important name reactions
Syn the Sizer
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[*] posted on 4-4-2020 at 19:35
10 most important name reactions


Hey everyone, I am wondering what people feel are the 10 most crucial name reactions. I have been wanting to focus on better understanding name reactions. I have been reading on the Aldol addition/condensation reactions and have considered doing a couple of the reactions I have discovered.

Thanks
Syn
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draculic acid69
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[*] posted on 4-4-2020 at 20:17


Grignard rxn
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Texium (zts16)
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[*] posted on 4-4-2020 at 20:20


I don’t think that there’s an objective list, but here’s 10 good ones off the top of my head that you should look into, in no particular order:

-Grignard Reaction
-Wolff-Kishner Reduction and Clemmensen Reduction (same function, different reagents)
-Wittig Reaction
-Claisen Condensation
-Sandmeyer Reaction
-Fischer Indole Synthesis
-Diels-Alder Reaction
-Mannich Reaction
-Hofmann Degradation
-Michael Addition/Robinson Annulation

There’s also a whole host of palladium catalyzed couplings that are very important and useful, but not very practical for the amateur. Some important variants:
Suzuki Coupling, Heck Coupling, Sonogashira Coupling, Stille Coupling




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j_sum1
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[*] posted on 4-4-2020 at 21:16


Birch reduction?
Fischer esterification?
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draculic acid69
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[*] posted on 4-4-2020 at 22:00


Excellent suggestions guys.these are the most common rxns one usually encounters in an amateur lab setting.
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Sulaiman
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[*] posted on 4-4-2020 at 23:11


Haber–Bosch process and Ostwald process
not sure if they qualify as named reactions, but they are super important.




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Sigmatropic
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[*] posted on 4-4-2020 at 23:15


Based on FMO theory there are only 9 reactions. Perhaps 12 if you count the pericyclic ones as separate reactions. All you need to know.

Scrap that, there are only 9 reactions.

[Edited on 5-4-2020 by Sigmatropic]
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Metacelsus
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[*] posted on 5-4-2020 at 05:34


Only 9 reactions?

I think you're forgetting all the radical reactions. (Or possibly remembering radical reactions, and forgetting photochemical ones.)

Let's make a list. I'll go over my notes from undergrad, and count reverse reactions as the same reaction.

Non-radical, non-pericyclic:
Concerted nucleophilic additions (eg SN2, or addition to an alkene)
Heterolysis (carbocation formation)


Pericyclic (could be non-photochemical or photochemical, so x2):
Cycloadditions (eg Diels-Alder)
Electrocyclic rearrangement (eg cyclobutene <-> butadiene)
Sigmatropic (eg Cope or Claisen)
Group transfer (eg ene reaction)

Radical:
Bond homolysis (and reverse, radical recombination)
Abstraction
Single-electron transfer

So, that's already 13 classes of reactions just from my undergrad O-chem notes.

And there are some more weird things which I'm not sure how to classify, like the Bergman cyclization. This list probably isn't complete.

[Edited on 2020-4-5 by Metacelsus]




As below, so above.
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clearly_not_atara
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[*] posted on 5-4-2020 at 05:37


zts's list is pretty good, but I would suggest some changes:

- replace Claisen with Knoevenagel condensation
- drop Hofmann and Mannich rxns
- add Huisgen "click" cycloaddition
- honestly not sure if Grignard should be listed since everyone seems to use lithium these days
- add Swern oxidation (with its many variations)
- add Mitsunobu reaction
- would probably choose Heck as the primary representative of Pd-catalyzed couplings

I'm not sure if there's a general term for alkyne or allene-mediated annulation but that's a pretty important technique today also.




[Edited on 04-20-1969 by clearly_not_atara]
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Syn the Sizer
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[*] posted on 5-4-2020 at 09:49


Quote: Originally posted by Sulaiman  
Haber–Bosch process and Ostwald process
not sure if they qualify as named reactions, but they are super important.


I didn't think the Aldol reaction was a name reaction but when I googled name reactions it shows up on lists. I always though name reactions were named after the Chemist. I have found lists with tons of reactions and it gets overwhelming so that's why I came here to ask.

Thanks everyone for the replies.
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DrIronic101
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[*] posted on 7-4-2020 at 12:30


Friedel-Crafts Acylation
Henry Reaction
Grignard Reaction
Knoelvagel Condensation
Fisher Esterification
Williamson Ether Synthesis
Reductive Amination (not technically a named one but still super important)

To name a few.




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mackolol
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[*] posted on 8-4-2020 at 01:50


Reimer - Tiemann reaction is very useful
Meerwein - Ponndorf - Verley reduction is the most basic reaction when you want to reduce ketone to alcohol or vice wersa

These are the two that come to my mind at the moment.
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[*] posted on 8-4-2020 at 04:13


Hofmann rearrangement



acid that repeat its qualities called "Periodic acid".
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Syn the Sizer
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[*] posted on 8-4-2020 at 21:56


Awesome. Lots to look into and study, thanks again everyone.
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