DrIronic101
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Registered: 16-9-2019
Location: Western United States
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Modified synthesis of chloroquine, beginning from benzoic acid
I modified my write-up of a total synthesis of chloroquine, including a different route to 7-chloro-4-hydroxyquinoline and a route to the amine
precursor, 4-diethylamino-1-methylbutylamine. I would be interested to see if anyone is willing to attempt this synthesis at some point in time.
Attachment: Chloroquine Write-Up 2.pdf (569kB)
This file has been downloaded 329 times
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AvBaeyer
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Registered: 25-2-2014
Location: CA
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This looks like one of those sophomore org chem road map problems. You might find it instructive, since you are a student, to estimate the yield of
each proposed step based on literature searches. This would give you an idea of how many barrels of benzene you would need to get a measurable amount
of product at the end.
I do not mean to be snarky but your proposal needs more in depth analysis before anyone would start it.
AvB
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