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Author: Subject: Recrystallization questions
ketadd
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[*] posted on 17-3-2011 at 13:19
Recrystallization questions


How do I go about researching a proper solvent system for purification of a specific substance or class of substances?

For example, I`d like to know what solvents are used to recrystallize Testosterone Enanthate which is a steroid? I`ve done some searchs and came across aqueous methanol as a possibillity.

I guess what I`m asking is for some help finding information on how to figure out what solvents to use for specific compounds for recrystallization.
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ScienceSquirrel
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[*] posted on 17-3-2011 at 14:39


For most organic compounds the best way is to look at the literature that details their synthesis or if dealing with a new compound, compounds that are similar to it.
Chemistry is an art as well as a science. An experienced chemist can tease out crystals using cooling, solvent layering, etc.
It was said that the old German chemists could seed a solution with the detritus that fell from their beards! :)
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White Yeti
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[*] posted on 29-7-2011 at 06:12


Usually, you would look at how polar the molecule is in relation to familiar substances that have concrete dipole moments.
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