Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: Good solvent for liquid liquid extraction of curcuminoids
alchemizt
Harmless
*




Posts: 36
Registered: 28-1-2019
Member Is Offline


[*] posted on 28-5-2022 at 18:14
Good solvent for liquid liquid extraction of curcuminoids


I made an extract of turmeric with 96% ethanol and evaporated the solvent at room temperate with a fan. The solvent won't evaporate completely due to the water. I'm thinking of using a liquid liquid extraction to separate the oil and curcuminoids from the water. Acetone is well known to be exceptionally good for dissolving curcuminoids, but its miscible with water. Would ethyl acetate be the next best thing?
View user's profile View All Posts By User
Boffis
International Hazard
*****




Posts: 1726
Registered: 1-5-2011
Member Is Offline

Mood: No Mood

[*] posted on 28-5-2022 at 23:09


That's not the way to go! Dry over calcium chloride or sulphuric acid etc and then leach the residue with petroleum ether/ cyclohexane etc to remove fats and oils and then recrystallise from a hot alcohol. I can't remember which alcohol I used and I am not at home to check my notes but it does make a difference. This latter process gives you fairly pure curcumin and a residue that contains at least 3 well crystallised substances.
View user's profile View All Posts By User
unionised
International Hazard
*****




Posts: 4934
Registered: 1-11-2003
Location: UK
Member Is Offline

Mood: No Mood

[*] posted on 29-5-2022 at 01:47


Quote: Originally posted by alchemizt  
The solvent won't evaporate completely due to the water.

It probably isn't water.
There are fats and oils in the spice and those will have been extracted along with the curcumin.

As Boffis has pointed out, you can remove them by extraction with pet ether (and you can use zippo fuel if you don't have access to pet ether).

That takes care of the fats.
But there will still be other things present- notably sugars.
a wash with water will remove them- though there will be some (small) loss of curcumin.

Recrystallisation is still a good plan.
View user's profile View All Posts By User
alchemizt
Harmless
*




Posts: 36
Registered: 28-1-2019
Member Is Offline


[*] posted on 30-5-2022 at 07:20


Quote: Originally posted by Boffis  
That's not the way to go! Dry over calcium chloride or sulphuric acid etc and then leach the residue with petroleum ether/ cyclohexane etc to remove fats and oils and then recrystallise from a hot alcohol. I can't remember which alcohol I used and I am not at home to check my notes but it does make a difference. This latter process gives you fairly pure curcumin and a residue that contains at least 3 well crystallised substances.


I actually wanted to isolate the oleoresin (mix of curcuminoids and essential oil) and save some of that, then separate the curcuminoids from that. Does the alcohol recrystallisation give you pure curcumin or a mix of 3 curcuminoids?
View user's profile View All Posts By User
pneumatician
National Hazard
****




Posts: 372
Registered: 27-5-2013
Location: Catalonia
Member Is Offline

Mood: ■■■■■■■■■■ INRI ■■■■■■■■■■ ** Igne Natura Renovatur Integra **

[*] posted on 2-8-2022 at 09:59


freezer??
View user's profile View All Posts By User

  Go To Top