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Author: Subject: Aminoxytriphene possible new synthesis
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[*] posted on 12-1-2026 at 16:03
Aminoxytriphene possible new synthesis


Can someone check this for me please? I think I came up with a new route to Amotriphene that has hitherto not been reported in the literature before.

https://en.wikipedia.org/wiki/Aminoxytriphene#Synthesis

One plausible disconnection approach to the synthesis relies on trianisylethylene.[8][9] This would undergo an olefin Mannich (vs aza‑Prins) to give the product although this is not empirically proven and was only conjectural (checked with AI). This unusual olefinic version of the Mannich reaction has been described for Zolpidem as well as Alpidem, for example.

Ofcourse this is not the actual literature procedure that was published involved Mannich reaction to desoxyanisoin followed by organometallic addition of anisyl magnesium bromide and dehydration of the resulting alcohol.[10]

Г. Хухр нский Л. Н. Волове льский, SU213825 ().
Robert S Shelton & Jr Marcus G Van Campen, U.S. patent 2,571,954 (1951 to WM S MERRELL CO).
Elpern Bill, U.S. patent 3,010,965 & U.S. patent 3,161,646 (1961 & 1964 both to Sterling Drug Inc).
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[*] posted on 12-1-2026 at 16:21


http://repository.sustech.edu:8080/bitstream/handle/12345678...
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