uchiacon
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sodium borohydride to sodium triacetoxyborohydride
Hey guys,
I'm interested in making a bit of sodium triacetoxyborohydride for future reductive aminations (just got a 1st yr uni organic chem book), and I was
just wondering how I could go about this? I saw something about dissolving it in ethyl acetate and adding a few moles of glacial acetic, but I did not
find anything more, as the synthesis was incomplete. Google hasn't turned up anything else.
I'm not sure if this is feasible, but any suggestions would be great.
I've just gotten back into organic chemistry, which I almost dropped a year ago. I was doing pyrotechnics and energetic materials, but I decided to
stop for want of expensive safety equipment. Now that I'm doing more complex chemistry in high school, I know I should definitely take this as part of
my career.
cheers
"If an injury has to be done to a man it should be so severe that his vengeance need not be feared."
Before you find youself cheering for a new regulation, consider your reaction if you were to be on the receiving end.
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tmb
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Make it in-situ. Here is a review:
Attachment: NaBH4 in Carboxylic Acid Media.pdf (434kB)
This file has been downloaded 1191 times
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jon
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ethylacetate is a great solvent for stab
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uchiacon
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hm, I meant triacetoxyborohydride, this looks like it's for acyloxyborohydrides... was there a bit of a mix up here? triacetoxyborohydride is only
mentioned once in the whole document.
"If an injury has to be done to a man it should be so severe that his vengeance need not be feared."
Before you find youself cheering for a new regulation, consider your reaction if you were to be on the receiving end.
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tmb
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It is mentioned many times. If you must isolate it, here is how:
NaBH4 (0.1 mol.) was added portionwise to a solution of acetic acid (0.33 mol.) in dry benzene (1 l.), the temperature being kept at 20C. After
hydrogen evolution, the precipitate was rapidly collected by suction, washed with diethyl ether, and dried under vacuum.
[Edited on 20-7-2011 by tmb]
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Nicodem
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Quote: Originally posted by uchiacon  | | I'm interested in making a bit of sodium triacetoxyborohydride for future reductive aminations (just got a 1st yr uni organic chem book), and I was
just wondering how I could go about this? |
You could go about this by UTFSE. The most basic skill of every good researcher is the use of TFSE.
PS: Open referenceless threads only in the Beginnings section, where this one is being moved.
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Nicodem
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Thread Moved
20-7-2011 at 12:30 |
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