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Author: Subject: List of enzymes in human blood
Fusionfire
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[*] posted on 1-5-2012 at 07:18
List of enzymes in human blood


Hello folks,

I hope everyone is having a great week! :)

Does anyone here have a list (preferably with references) of a list of enzymes present in human blood?

I am especially interested in the enzymes present in blood during a wound/injury.

Thanks.
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Neil
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[*] posted on 1-5-2012 at 07:21


*cough* beginnings *cough*


...a starting place...
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Fusionfire
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[*] posted on 1-5-2012 at 07:28


Thanks. My background is in aerospace engineering so please excuse my ignorance in the subject.

For the work I am putting together, at this stage all I really need is a list of enzymes.
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MountainMan
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[*] posted on 1-5-2012 at 07:57


I'm a medical laboratory director so maybe I can help but you'll have to narrow down your inquiry for it to be helpful. What organ/tissue type are you speciifcally looking for in terms of injury e.g., heart, liver ?
If you don't want to post it for some reason, send me an email.
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Fusionfire
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[*] posted on 1-5-2012 at 08:32


Hello, for now, I'm interested in enzymes in a generic wound profile such as you might get with the clotting mechanism or basically always present in human blood.

For example we have looked at catalase, which is interesting because of its high turnover number. Unfortunately it is proving difficult to design a device that can single out catalase in blood without reacting to other sources of catalase in the environment, such as ubiquitous staphylococci.
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phlogiston
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[*] posted on 1-5-2012 at 13:40


The list you want is very, very long.
Thousands of different enzymes and proteins exist in blood and the different types of cells in it. Some are very abundant (albumin, for instance), while others are present in only minute quantities.

Although you do not explain the goal, your last post suggests that you are looking for a marker for blood.

The prokaryotic catalases are likely to be different enough from the human enzyme that it should be possible to raise antibodies that are specific for the human catalase. Actually, such antibodies may well be commercially available already.

The list of proteins present in a biological sample is called a 'proteome' these days. Using the search terms 'proteome' and 'blood' (or plasma, or serum, or erythrocyte, or ...) will give a large number of hits some of which look promising. Try pubmed or google scholar




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White Yeti
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[*] posted on 1-5-2012 at 15:06


Instead of repeating the fact that the list is very long (which it is), I'll start it off:
Carbonic anhydrase
Thrombin
Prothrombin
Serine protease
Plasma thromboplastin
Transglutaminase
[edit]
These may be helpful:
http://ms.cc.sunysb.edu/~jjesty/coag.pdf
http://www.cap.org/apps/docs/cap_press/hemostasis_testing/co...
http://bloodjournal.hematologylibrary.org/content/4/12/1290....
http://www.manidistrega.info/pdf/bloodclotting/2.pdf

[Edited on 5-2-2012 by White Yeti]




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