Aqua-regia
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2,6-dichlororo pyridine 4 carboxilic acid reduction to isonicotinic acid
I am looking to synthesize isonicotinic acid from citrazinic acid. The route to get 2,6-dichloro-pyridine-4 carboxilic acid was easy, but the
reduction of halogen need a cheap procedure. (no hydrazine and LiAlH) A little bit of preliminary googling I found this:
What is your opinion about this things
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Weinreb
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I have performed the Mg/isopropyl alcohol reduction on chlorobenzene, yield was excellent on this substrate. The magnesium was standard turnings used
for Grignard reactions.
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Aqua-regia
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Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.
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Dr.Bob
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Quote: Originally posted by Aqua-regia  | | Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.
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Huh?
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