ChemicallyImbalanced
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Niacin ---> Pyridine (HCl)
Is it possible to remove the carbamoyl group from Niacin and rearrange its ring structure to give Pyridine? I assume this cannot be done, but if it
can how would I go about doing so?
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Marvin
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Yes, this has been covered at E&W, and possibly here as well. Usual NaOH/CaO method should work but the beta carboxylic acids are rather more
stubborn than alpha or gamma. I dont think anyone has tried the method yet.
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Esplosivo
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If you're about to prepare pyridine, and you're male, I would check out the MSDS. Pyridine can do some nasty things to your reproductive
system in large enough conc. Take the necessary precautions. Just an advice.
Theory guides, experiment decides.
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ChemicallyImbalanced
surly adolescent
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I searched the forum here and didn't find anything on this, but where is E&W? Do you have any refs for this procedure? I searched all over
and couldn't find anything of this nature. I did find many papers and patents about the reverse process though. Mostly 3-methyl Pyridine to
Niacin and the like. I'm thinking a vigorous boil with 10% NaOH solution would do it. Any thoughts on that?
"Pyridine can do some nasty things to your reproductive system in large enough conc.”
I'm pretty much done laying my seeds.  I doubt anyone would want to have
my children anyway. 
[Edited on 15-12-2004 by ChemicallyImbalanced]
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The_Davster
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E&W is www.roguesci.org
I believe this is the thread you want
http://www.roguesci.org/theforum/showthread.php?t=3289&h...
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Marvin
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Standard method for decarboxylation of an aromatic ring is to mix the acid with a large excess of CaO, or CaO and NaOH, or even just NaOH and
destructivly distill. Organikum has a thread here on production of benzene from sodium benzoate or benzoic acid. Worth a read.
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ChemicallyImbalanced
surly adolescent
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OK... thanks for the help.
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