Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: Psycho biochemistry forums?
Hazard to Others

Posts: 133
Registered: 13-10-2003
Member Is Offline

Mood: No Mood

[*] posted on 18-4-2005 at 04:48
Psycho biochemistry forums?

I should write a paper about MAO-inhibitors. So Im looking for a psycho chemistry forums similar to The Hive (which is down since long). Could you help me?

I also wonder:
1. Could lazyness in healthy subjects possibly be "cured" to some extent by adminstering L-dopa? What would happen if healthy people eat increase dopamine levels by L-dopa?

2. Suppose someone wants to increase training results from wiegthlifting. Which risks are associated with using insuline to increase metabolism? (Not including overdose ofcourse)
View user's profile View All Posts By User
International Hazard

Posts: 1234
Registered: 16-1-2005
Location: not where you think
Member Is Offline

Mood: chaotropic

[*] posted on 18-4-2005 at 05:43

Hi Wolfram!

1. Levodopa is an amino acid naturally produced by the body as a precursor to the neurotransmitter dopamine, which is in turn the precursor of epinephrine and norepinephrine. Dopamine acts as a sort of "slow down" signal to neurons, such that humans are capable of doing their day-to-day activities.

As to using levodopa to "cure" laziness, I am not certain. As you may know, laziness can be due to a lot of things, apart from hormonal imbalances.

With healthy people, not much effect may be noticed since dopamine is continuously produced and metabolized. Besides, not all of the dopamine thus produced will cross the blood-brain barrier; most of it will be further metabolized. So administering excess levodopa may just be a waste.

2. In the case of using insulin to boost metabolism, I would tend to think that the administration of extra insulin if the subject is producing normal amounts of it might constitute upsetting the body's delicate balance. If the pituitary gets wind of excess amounts of insulin coasting in the bloodstream, it would then send a chemical message to the isles of Langerhans saying to produce less insulin, which would be counterproductive to your goal of increasing metabolism. Thus, maybe the guy can weightlift, but if he's not diabetic/hyperglycemic, he ought to skip the insulin shots.

Hope this helps. As to forums, Synthetika may be a good forum to ask questions also. :)

sparky (^_^)

"What's UTFSE? I keep hearing about it, but I can't be arsed to search for the answer..."
View user's profile View All Posts By User
Hazard to Others

Posts: 491
Registered: 7-2-2004
Location: Mediterranean
Member Is Offline

Mood: Quantized

[*] posted on 18-4-2005 at 05:53

Well dopamine is not exactly a slow down chemical sparkgap, it is more of a stimulant. It acts on the sympathetic nervous system, producing fright-and-fight/flight reactions - increased heart rate, stops peristalsis, increased blood pressure, etc... L-dopa on the other hand, might not be converted to dopamine. An excess is mostly probably simply metabolised and broken down at the liver most probably, as sparkgap said. Increased tyrosine levels, precursor of L-dopa, for example, would not increase dopamine levels. They body tends to maintain concentrations within a narrow limit, and it is rather efficient and does this in a short time. As a side note, dopamine is involved in what are known as the 'pleasure' pathways/responses. Therefore they would make one feel more excited, if so may be said. One could administer drugs which are said to increase dopamine levels (such as cocaine), although this theory is as far as I know, not confirmed and neither beneficial, until new drugs are found which do not bring about so many side effects.

In the case of insulin I agree completely with sparkgap. Besides increased insulin levels would cause more glucose to be stored up by conversion into glycogen and/or fat. This would reduce blood glucose levels beyond the 80mg/100mL of blood, which would surely not supply a weight lifter with the nergy he requires.

[Edited on 18-4-2005 by Esplosivo]

Theory guides, experiment decides.
View user's profile Visit user's homepage View All Posts By User

  Go To Top