Flip
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3-phenyl-1,1,1-triflouroacetone
I ran across 3-phenyl-1,1,1-triflouroacetone in a catalog. aka. benzyl trifluoromethyl ketone, or 1,1,1-trifluoro-3-phenyl-2-propanone.
I can't help but wonder... is there anything I can do with this molecule synthetically. Is there perhaps a good way to remove the
three terminal flourines? 
Wishful thinking probably.
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Lord_Worm
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hahah wat u trying to get.Phenylacetone
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Sandmeyer
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if you ever sucseed in doing this - send your synthesis to The Journal of Unpublished Chemistry, latest issue features:
The total synthesis of triethyl ammonium hydrobromide from expensive, difficult to prepare starting materials.
Abstract: Triethyl ammonium hydrobromide was synthesised in excellent yield from N-tertbutyldimethylsilanyl-4-bromo azetidinone in a single step.
http://jun.lemonie.net/NEt3HBr.html
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stoichiometric_steve
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| Quote: | Originally posted by Flip
Is there perhaps a good way to remove the three terminal flourines?
Wishful thinking probably. |
are you kidding.
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Flip
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Uhhh... no. I'm really not kidding. Enlighten me.
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turd
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The C-F bond is one of the strongest bonds you will find in organic chemistry. Good luck in breaking it.
But why don't you try to make the corresponding (meth)amphetamine (try saying atfmphetamine aloud!) and characterise it? That would be interesting -
more so than dull amphetamine.
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Nicodem
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Substituting the alpha-methyl group with the trifluoromethyl abolishes amphetamine-like activity in amphetamine. At least according to Pinder, Burger
, J. Pharm. Sci. 56 (1967) 970. Other electron withdrawing groups, like the cyano for example, have similar effect. Only the electron
donating groups (Et, allyl, ethynyl ) maintain some amphetamine-like activity in animal models.
…there is a human touch of the cultist “believer” in every theorist that he must struggle against as being
unworthy of the scientist. Some of the greatest men of science have publicly repudiated a theory which earlier they hotly defended. In this lies their
scientific temper, not in the scientific defense of the theory. - Weston La Barre (Ghost Dance, 1972)
Read the The ScienceMadness Guidelines!
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