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Author: Subject: Amphetamine from Cinnamaldehyde
stoichiometric_steve
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[*] posted on 11-8-2008 at 00:20


Quote:
Originally posted by Vitus_Verdegast
2. At room temperature dehydration of 3-phenyl-1-propanol yields allylbenzene as the main product. For example, treatment of allylbenzene with SOCl2 yields chiefly allylbenzene and a small amount of propenylbenzene.
ref: Compt. Rend. 186 (1928) p. 1301, 1626, 1848


i couldn't find any experimental part in that reference.




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swip2
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sad.gif posted on 11-8-2008 at 16:31
refs


Could those refs be posted
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solo
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[*] posted on 11-8-2008 at 19:05


Quote:
Originally posted by stoichiometric_steve
Quote:
Originally posted by Vitus_Verdegast
2. At room temperature dehydration of 3-phenyl-1-propanol yields allylbenzene as the main product. For example, treatment of allylbenzene with SOCl2 yields chiefly allylbenzene and a small amount of propenylbenzene.
ref: Compt. Rend. 186 (1928) p. 1301, 1626, 1848


i couldn't find any experimental part in that reference.


Attachment: Franch journal allylbenzene synthesis info.pdf (403kB)
This file has been downloaded 1785 times





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S.C. Wack
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[*] posted on 12-8-2008 at 01:07


Quote:
Originally posted by swip2
Could those refs be posted

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Right backatcha. Perhaps you could download it yourself from Gallica like stoichiometric_steve did.

Related some to some posts in this thread...there is another dehydration of hydrocinnamyl alcohol in the literature that I'm aware of.

But it is as an ester and the product was allylbenzene.

Hydrocinnamyl acetate, b.p. 133° (18 mm.) (61 g., 0.34 mole) was passed over glass wool heated at 460-485°. The pyrolysis product was washed with aqueous sodium carbonate solution, dried and distilled at atmospheric pressure. The yield of allylbenzene, b.p 150-160°, was 31 g. (76%).
-JACS 78, 584 (1956)
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swip2
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[*] posted on 15-8-2008 at 18:41


Well the link is all good and everything but Its In French ffs :o..

Is it possible for anyone to translate it, Or provide a link to an english version...

Dose stoichiometric_steve have it in english.

And could S.C. Wack please provide a refrence to the hydrocinnamyl alcohol comment please.
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stoichiometric_steve
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[*] posted on 16-8-2008 at 00:45


i can read french pretty well but it has NO experimental section.
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[*] posted on 19-8-2008 at 12:37


There is at least one reference to researchers having a-brominated cinnamaldehyde to the 2-bromo, which was reduced with yeast to the wanted a-bromophenylpropan-3-ol. The researchers in question claim seriously high enantio-ratios, in using this process for making phenylalaninol/phenylalaninal (I think Solo will know the reference I refer to*). Yeast reduction seems to be a useful route to enantiospecificity, which in the case of such chiral compounds might make it worth a look.

Once you have n-methylphenylalaninol then a number of options open up, the scientific interest would be in the economical production of anti-retroviral agents (which is what the paper deals with). It would be nice if someone could come up with a synthesis for pirating such agents, given that the pharm. companies continue to charge incredible prices (well beyond the means of most sufferers).

* IIRC the part-title makes reference to 'Yeast reduction of cinnamaldehyde derivatives...'?
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[*] posted on 19-8-2008 at 16:49


http://wizardx.t35.com/achive/cinnamic.html

The site in question was violating our TOS and was removed.

I'll upload it again soon.

[Edited on 20-8-2008 by WizardX]




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[*] posted on 6-3-2012 at 11:51


Quote: Originally posted by Nicodem  
Quote:


I would say the reduction to cynamyl alcohol (or its aquisition given that it's pretty cheap), substitution with conc. HCl to yield cynamyl chloride, reduction with Zn/AcOH to yield 1-phenylpropene from which the route proceeds by well known reactions.


Would this be a valid route to (ref attached) cynnamyl chloride? This seems like the Holy Grail of OTC routes

Attachment: THE_REACTION_BETWEEN_ALCOHOLS_AND_AQUEOUS_SOLUTIONS_OF_HYDROCHLORIC_AND_HYDROBROMIC_ACIDS..pdf (671kB)
This file has been downloaded 1327 times

[Edited on 6-3-2012 by zgoat65]

[Edited on 6-3-2012 by zgoat65]




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[*] posted on 6-3-2012 at 17:39


"There is a reference to the bromination of cinnamyl alcohol in Organic Synthesis (http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv5...).

The authors cite a 1918 German paper where it is claimed that cinnamyl bromide can been prepared from cinnamyl alcohol by the action of hydrogen bromide in cold acetic acid. I'm don't know why these conditions wouldn't also brominate the alkene double bond. I don't have access to the paper so I'm afraid I can't help more. You might be able to brominate the alcohol and the halide in one step. If you could selectively dehalogenate the primary, you should be able to from the 2-Bromo-1-phenylpropane. You can then convert the halide to the iodide with the Finkelstein reaction in acetone. (http://en.wikipedia.org/wiki/Finkelstein_reaction). Finally you should be able to aminate the iodide with methylamine in dry IPA as ++++ has shown with iodosafrole."w

Taken from a thread elsewhere

[Edited on 7-3-2012 by zgoat65]

cinnamyl_alchohol_to_MA-1.gif - 20kB

[Edited on 7-3-2012 by zgoat65]




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cal
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[*] posted on 9-3-2012 at 07:23


Quote: Originally posted by Sandmeyer  
Filemon, those links as provided do not prove your point. However, yield of propenylbenzene by the reduction of cinnamic aldehyde is 70% using Huang-Minlon variant of Wolff-Kishner:

http://rapidshare.de/files/28334409/huang.pdf.html

I meen you can't go from that aldehyde for the sake of going from there, even if it involves hydrazine reduction, hinz even suggests Grignard. If this starting material is to be used then I like Nicodems idea of making alcohol, then chloride, then OTC reduction. But to get to propenylbenzene you could go from propiophenone (cheap, IMO probably the best single precursor if you're interested in simple stimulants [including phenmetrazine, which at least Swedish speedfreaks prefer over methamphetamine according to Wikipedia, and one such person did report it better than amph on bluelight]
and have no regard for the law), reduce and dehydrate with tosic or sulfuric. Hell, there are other smoother ways of doing this, but amphetamine dosen't interest me, so you find out..

That link does not exist anymore so if you have a copy, then post it and do not reference it.

[Edited on 6-8-2006 by Sandmeyer]
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[*] posted on 10-3-2012 at 07:56


"The authors cite a 1918 German paper where it is claimed that cinnamyl bromide can been prepared from cinnamyl alcohol by the action of hydrogen bromide in cold acetic acid. I'm don't know why these conditions wouldn't also brominate the alkene double bond. I don't have access to the paper so I'm afraid I can't help more. You might be able to brominate the alcohol and the halide in one step. If you could selectively dehalogenate the primary, you should be able to from the 2-Bromo-1-phenylpropane. You can then convert the halide to the iodide with the Finkelstein reaction in acetone. (http://en.wikipedia.org/wiki/Finkelstein_reaction). Finally you should be able to aminate the iodide with methylamine in dry IPA as ++++ has shown with iodosafrole."w"

........in your last sentence...."Finally you should be able to aminate the iodide with methylamine in dry IPA as ++++ has shown with iodosafrole."w"......do you have a reference for that statement?.......solo




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[*] posted on 21-3-2012 at 10:24


OR...........how bout this ref? Forget halogenation/dehalogenation, and go from alcohol to olefin using amalgamated zinc?

http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6...




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[*] posted on 25-3-2012 at 10:03
License


Quote: Originally posted by Filemon  
Quote:
Originally posted by Vitus_Verdegast


Be aware that in most countries it is a felony to produce and/or possess amphetamine without a license.





[Edited on 4-8-2006 by Vitus_Verdegast]


Of course, they allow me microsynthesis but it should be immediately destroyed.

Along with most all chemicals we want to buy now. That does not stop us from making what we need.
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[*] posted on 25-3-2012 at 10:07
Link


Quote: Originally posted by cal  
Quote: Originally posted by Sandmeyer  
Filemon, those links as provided do not prove your point. However, yield of propenylbenzene by the reduction of cinnamic aldehyde is 70% using Huang-Minlon variant of Wolff-Kishner:

http://rapidshare.de/files/28334409/huang.pdf.html

I meen you can't go from that aldehyde for the sake of going from there, even if it involves hydrazine reduction, hinz even suggests Grignard. If this starting material is to be used then I like Nicodems idea of making alcohol, then chloride, then OTC reduction. But to get to propenylbenzene you could go from propiophenone (cheap, IMO probably the best single precursor if you're interested in simple stimulants [including phenmetrazine, which at least Swedish speedfreaks prefer over methamphetamine according to Wikipedia, and one such person did report it better than amph on bluelight]
and have no regard for the law), reduce and dehydrate with tosic or sulfuric. Hell, there are other smoother ways of doing this, but amphetamine dosen't interest me, so you find out..

That link does not exist anymore so if you have a copy, then post it and do not reference it.

[Edited on 6-8-2006 by Sandmeyer]

Do you have this document as the download link is no longer available.
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ScienceSquirrel
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[*] posted on 8-4-2012 at 21:21


Quote: Originally posted by Sandmeyer  

http://rapidshare.de/files/28334409/huang.pdf.html





[Edited on 6-8-2006 by Sandmeyer]

Could you repost without using rapidshare? It's really volatile. That link was dead within a few days and I missed it.




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[*] posted on 9-4-2012 at 11:43


It's in any arcHive, with Huang-Minlon_propenylbenzene in the file title. Not convenient to quote from.



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[*] posted on 10-5-2015 at 13:44
Dihydrocinnamyl alcohol dehydration


I read up on this and apparently you need either KHSO4 or conc. H2SO4 and high heat.
However, the product doesn't boil out, even being way past water's BP.

As far as I know, you should remove water but if you go beyond 80C, you get loads of side-reaction product.

Is it possible that (PhCH2CH2CH2)2O is formed and that's why you don't dehydrate?
In that case: can I take say 3 equiv EtOH and 1 equiv PhCH2CH2CH2OH to form the ethyl ether of dihydrocinnamyl alcohol (along with Et2O), then use KHSO4 at 80C to eliminate EtOH while removing it and leaving behind allylbenzene?
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[*] posted on 10-5-2015 at 14:47


Why don't you post what you have read, as this section generally requires references?
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[*] posted on 11-5-2015 at 00:30


Apologies, here: http://chemistry.mdma.ch/hiveboard/chemistrydiscourse/000204...
Before you get any wrong idea: the alkene is at the end position, so wacker or performic or whatever won't work, you need a catalyst under inert atmosphere to rearrange it to the middle ;)
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[*] posted on 11-5-2015 at 02:12


You should probably add in that the beckmann will also not work on this substrate...
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[*] posted on 11-5-2015 at 04:01


No carbonyl, no beckmann ;)
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[*] posted on 11-5-2015 at 06:34


seriously though, any help here please?
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[*] posted on 11-5-2015 at 15:41


My experience with acrolein tells, that you will get some solid gummy tar as a product, unless you distill your dehydrated product as fast as it is formed.
Allylbenzene has b.p. 156-157°C, so this procedure can be performed pretty easily, until you condense the product back to where it will polimerize.
Those compounds are usually processed in gas phase via heterogenous catalyst, thus ensuring a short contact time.
PS: the problem is called "acid catalyzed alkene polimerization".

[Edited on 11-5-2015 by byko3y]
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[*] posted on 12-5-2015 at 04:53


fair, solid input, thank you :)
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