Melgar
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Halide-free Friedel-Crafts acylation, using P2O5 as both Lewis acid and acid dehydrator
By supporting phosphorus pentoxide on silica gel, because otherwise it turns into a sticky mess and stops reacting, researchers were able to perform
Friedel-Crafts acylation starting with the organic acids (rather than acid halides or acid anhydrides) and the aromatic substrate. This would result
in superior yields to ordinary Friedel-Crafts with an acid anhydride, since the anhydride reforms after it reacts. Paper is attached.
Attachment: p2o5-friedel-crafts.pdf (313kB)
This file has been downloaded 406 times
[Edited on 10/24/16 by Melgar]
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myristicinaldehyde
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Chemplayer has a video on this too-https://www.youtube.com/watch?v=xAUlglOiVos
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