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Author: Subject: Easy pyridine synth. found in a paper, does it work?
subskune
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[*] posted on 12-7-2017 at 00:07


Reading your suggestion multiplied my interest in this synthesis. Not only because it seems to be promising to make pyridine derivates (its is lutidine). If the oxaloaceticacid amide reaction works... well that would make it easy and cheap to make m5 fiber.

I think of starting from malonic acid which I have in bulk add the amide groups using urea and oxidize (or the other way around). Using the hexamin reaction and bleach hoffmann rearrangement as DrDevice suggested:
Quote:

Following up on the idea from @Loptr, there are easier/more accessible Hofmann rearrangements than using Br2 etc. I've had success with ordinary chlorine bleach and NaOH. See:

http://www.sciencemadness.org/talk/viewthread.php?tid=65969


This would make the whole m5 fibre synth suitable for home production.




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CuReUS
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[*] posted on 12-7-2017 at 00:30


Quote: Originally posted by clearly_not_atara  

maybe oxaloacetic acid bis-amide would give the 1,4-dihydropyridine-2,3,4,5-tetracarboxamide which is a more direct precursor.

don't you mean 2,3,5,6-tetracarboxamide ?
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I had actually posted a thread about M5 synthesis once, consensus opinion was basically "it's tough"

the fiber or the synthesis:D ?


[Edited on 12-7-2017 by CuReUS]
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