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Author: Subject: The PhenylEthylAmine from Vanillin

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[*] posted on 27-11-2017 at 13:42
The PhenylEthylAmine from Vanillin

A lot of the current Amphetamines and PhenylEthylAmines described to be active psychedelics from works like PIKHAL, use the right substituted benzaldehyde as starting material.
Benzaldehyde itself is banned, but one of the most common aromatic aldehydes we have is Vanillin. The molecule poses a 4 hydroxy group and 3 methoxy group, hence some potential as a stimulant can be expected if its linked in the Amphetamine Backbone.
Sadly Shulgin didn't explore this compound because it contains a hydroxy group on the ring, something that doesn't occour in his book, maybe because they are inactive, but there is no mention to that.
Nevertheless, it would be amazingly simple to prepare;
Just the classic NitroEthane -> then reduction method
or NitroMethane -> Reduction (to the Phenyl Ethyl Amine )

Additionally, using Methyl Iodide with NaOH under reflux in DCM with the Vanelin would yield the Di-Methoxy Aldehyde which yields 3,4-DMA by our previos scheme, but the sad part is, Shulgin didn't extensively study this compound himself, but it is mentioned to have activity.

This Di Methoxy however can be converted to piperional, which is a precursor a drug that I won't mention;

It is a compound that is so easily made, but yet no one seems to be interested in it, I haven't heard clandestine chemist making 3,4-DMA or using Vanillin to make this other drug. This isn't encouragement to do so, but any idea's why this isn't being done ?
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[*] posted on 27-11-2017 at 15:22

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