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Author: Subject: 3,4-dimethylaminorex
jon
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[*] posted on 20-2-2007 at 16:10
3,4-dimethylaminorex


has anyone looked at the pharmacology of this anolog?
In this study they indicate the 4s,5s isomer as having dopaminergic nuerotoxicity and that it can induce fatal seizures that tells me this is very potent. They also indicate the maximum tolerable dose in rats is 5mg/kg 4s,5s, and 30 mg/kg for 4r,5s, where in the case of 4-methylaminorex it's 15mg. for both isomers (both cis and trans isomers).
Since a well known reaction pathway produces only a trans isomer it appears that it's possible to synthesize the "safer" isomer.


http://www.erowid.org/references/refs_view.php?A=ShowDocPart...

another reference I have is Buur, A.: Bundagar, H. arch. pharm., chem. sci. ed., 1987, 15, 76

Yuong-harvey, J.A.; Rae, I.D.: pitman, I.H. int. J. Pharm. 1986, 30, 151

Chalina, E.; Dantchev, D.; Georgiev, Mitova, k. Arch. Pharm, 1986, 319, 598

The article referenced on it's chemistry is
Poos, G.I.; Carson, J.R.; Rosenau, J.R.; Roszkouski, A.P.; Kelly, N.M.; Mcgrowin, J. J. Med. Chem., 1963, 5, 266

prepn. of the oxazolidine-2-imines from ephedrine:
Fodor, G.; Koczka, K. J. Chem. Soc., 1952, 850

Noggle, F.T. Jr.; clark C.R.; and Deruiter, J. J. AOAC int., 1992, 75, 423
[Edited on 21-2-2007 by jon]

[Edited on 21-2-2007 by jon]

[Edited on 21-2-2007 by jon]

[Edited on 21-2-2007 by jon]
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chemrox
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[*] posted on 22-2-2007 at 00:19


I'm going to be making the (3,4 MD)-4-MAR. I am sure its covered by existing patents but I have not read reports of its effects. I am very curious. Will it be psychedelic? Weaker stimulant? Anorexic? None of the above (most likely)? Or could it be a nootropic? Are you going to make the 3,4 dimethyl? Is it safe to do so? I hear the trans is technically unfettered with fed sores.
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jon
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[*] posted on 22-2-2007 at 15:48


the poos article I sent you would explain this they lose much of their activity when methoxylated in the 4-position I would'nt even bother.
when the 4-postition posesses an electron withdrawing substituent it's activity increased.
and technically the trans isomer is not scheduled but a weak circumstantial case has been made in the past and, that's all it takes. you see the law is grey when it should be black and white and vise versa.

[Edited on 22-2-2007 by jon]
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MeSynth
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sad.gif posted on 24-8-2011 at 13:56
found it


Found this on drug-forums after a google search for this neurotoxic isomer... No refs are provided. I haven't searched for them and probably won't. (this isn not the whole post)
--------------------------------------------
chemman added 6 Minutes and 10 Seconds later...

CHEMISTRY



N-Carbamyl-ephedrine .Potassium cyanate (2 g., 0.025 mole) was added to ephedrine hydrochloride (5 g., 0.025 mole) in water (25 ml.), and the solution then refluxed for 24 hours, during which a small amount of oil separated, and cooled in ice-salt. The dried, white plates of the urea (3 g; 57.7%) were crystallised from ethyl acetate and then had m.p. 126-127 deg C.



trans-2-Imino-3,4-dimethyl-5-phenyloxazolidine hydrochloride:
A solution of N-carbamyl-ephedrine (1.56 g., 0-075 mole) in water (24 ml.) and 2N-hydro-
chloric acid (15 ml.) was refluxed for 3 hours; when the clear solution cooled the crude oxazolidine hydrochloride was obtained. This was purified by conversion into the base (use Na2CO3 or K2CO3) which was extracted with benzene. The solvent was removed under vacuum from this, and the residue (direx freebase) converted into the hydrochloride (1-9g.; 84%), m. p. 225-229.
You can also use freebase to smoke or oral consumption.

--------------------------------------------------------------



1.jpg - 10kB2.jpg - 8kB
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spunonrun
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[*] posted on 6-9-2011 at 16:47


http://www.drugs-forum.com/forum/showthread.php?t=83865

[Edited on 7-9-2011 by spunonrun]
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Paddywhacker
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[*] posted on 6-9-2011 at 19:27


The N-Carbamyl-ephedrine is a urea. Look at the carbonyl flanked by two nitrogens.
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overload
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[*] posted on 1-10-2011 at 18:02


Quote: Originally posted by spunonrun  
http://www.drugs-forum.com/forum/showthread.php?t=83865

[Edited on 7-9-2011 by spunonrun]


Yeah thats where I got it. The other stuff is pretty useless and that's why I did not add the link. Does anyone have any idea if this really works? Spunonrun looks like he already knows....
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overload
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[*] posted on 1-10-2011 at 21:14


Aminorex has more potential as an anerectic.
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roamingnome
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[*] posted on 8-11-2011 at 20:23


stumbled on this "potent" paper


its seems that the methyl group of ephedrine prevents the double bond from being in the oxazoline ring so there is a imine type nitrogen ...whereas in methylaminorex you see a regular amino group. unless bond inversion is readily happening this may describe 5-HT2B antagonism ?

4dmar needs hydrogenation but not overly so
i am referring to page 851 fig (VIII)




prepn. of the oxazolidine-2-imines from ephedrine:
Fodor, G.; Koczka, K. J. Chem. Soc., 1952, 850


Attachment: dimetyloaminorex.jcs.1952.850.pdf (566kB)
This file has been downloaded 873 times

[Edited on 9-11-2011 by roamingnome]

[Edited on 9-11-2011 by roamingnome]
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Ephoton
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[*] posted on 10-11-2011 at 18:12


mdMAR is not active :)

dimethylAR or the 3,4methylaminorex is active at about 1/3 as potent as MAR.
I am suprised you do not know this it is very easy to get there.

aminorex is dangerous

and all of the MAR family are not selective enough and burn holes in your
head which lead to psycosis which can bee seen from MRI scans which are
freely available on the web.

there are better things to study than MAR.
it may be worth money but honest so are so many other things that dont
leave a shit hole for your kids to grow up in.

jon look into syringaldehyde into coke you might even save some
of our forests in the process.

it has been done by quite a few believe it or not :( .
still this substance is not what I would call progressive
development.

but hey its better than MAR substances.

safer is not dosage relative in my eyes.

its living after using.

[Edited on 11-11-2011 by Ephoton]




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jon
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[*] posted on 19-11-2011 at 19:23


yeah i can say you don't want to mess with these class of drugs i did and the end result was violent cconvulsions and sky high blood pressure.
the pressure was so great it was as if my head was about to explode.
dangerous stuff.




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11-12-2011 at 14:09

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